Publications

Displaying 101 - 167 of 167
  • Ozyurek, A. (1996). How children talk about a conversation. Journal of Child Language, 23(3), 693-714. doi:10.1017/S0305000900009004.

    Abstract

    This study investigates how children of different ages talk about a conversation that they have witnessed. 48 Turkish children, five, nine and thirteen years in age, saw a televised dialogue between two Sesame Street characters (Bert and Ernie). Afterward, they narrated what they had seen and heard. Their reports were analysed for the development of linguistic devices used to orient their listeners to the relevant properties of a conversational exchange. Each utterance in the child's narrative was analysed as to its conversational role: (1) whether the child used direct or indirect quotation frames; (2) whether the child marked the boundaries of conversational turns using speakers' names and (3) whether the child used a marker for pairing of utterances made by different speakers (agreement-disagreement, request-refusal, questioning-answering). Within pairings, children's use of (a) the temporal and evaluative connectivity markers and (b) the kind of verb of saying were identified. The data indicate that there is a developmental change in children's ability to use appropriate linguistic means to orient their listeners to the different properties of a conversation. The development and use of these linguistic means enable the child to establish different social roles in a narrative interaction. The findings are interpreted in terms of the child's social-communicative development from being a ' character' to becoming a ' narrator' and ' author' of the reported conversation in the narrative situation.
  • Ozyurek, A. (1994). How children talk about a conversation. In K. Beals, J. Denton, R. Knippen, L. Melnar, H. Suzuki, & E. Zeinfeld (Eds.), Papers from the Thirtieth Regional Meeting of the Chicago Linguistic Society: Main Session (pp. 309-319). Chicago, Ill: Chicago Linguistic Society.
  • Ozyurek, A. (1994). How children talk about conversations: Development of roles and voices. In E. V. Clark (Ed.), Proceedings of the Twenty-Sixth Annual Child Language Research Forum (pp. 197-206). Stanford: CSLI Publications.
  • Pederson, E., & Wilkins, D. (1996). A cross-linguistic questionnaire on 'demonstratives'. In S. C. Levinson (Ed.), Manual for the 1996 Field Season (pp. 1-11). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.3003259.

    Abstract

    Demonstrative terms (e.g., this and that) are key items in understanding how a language constructs and interprets spatial relationships. This in-depth questionnaire explores how demonstratives (and similar spatial deixis forms) function in the research language, covering such topics as their morphology and syntax, semantic dimensions, and co-occurring gesture practices. Questionnaire responses should ideally be based on natural, situated discourse as well as elicitation with consultants.
  • Pederson, E., & Roelofs, A. (1994). Max-Planck-Institute for Psycholinguistics: Annual Report Nr.15 1994. Nijmegen: MPI for Psycholinguistics.
  • Pederson, E., & Senft, G. (1996). Route descriptions: interactive games with Eric's maze task. In S. C. Levinson (Ed.), Manual for the 1996 Field Season (pp. 15-17). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.3003287.

    Abstract

    What are the preferred ways to describe spatial relationships in different linguistic and cultural groups, and how does this interact with non-linguistic spatial awareness? This game was devised as an interactive supplement to several items that collect information on the encoding and understanding of spatial relationships, especially as relevant to “route descriptions”. This is a director-matcher task, where one consultant has access to stimulus materials that shows a “target” situation, and directs another consultant (who cannot see the target) to recreate this arrangement.
  • Pine, J. M., Lieven, E. V., & Rowland, C. F. (1996). Observational and checklist measures of vocabulary composition: What do they mean? Journal of Child Language, 23(3), 573-590. doi:10.1017/S0305000900008953.

    Abstract

    Observational and checklist measures of vocabulary composition have both recently been used to look at the absolute proportion of nouns in children's early vocabularies. However, they have tended to generate rather different results. The present study is an attempt to investigate the relationship between such measures in a sample of 26 children between 1;1 and 2;1 at approximately 50 and 100 words. The results show that although observational and checklist measures are significantly correlated, there are also systematic quantitative differences between them which seem to reflect a combination of checklist, maternal-report and observational sampling biases. This suggests that, although both kinds of measure may represent good indices of differences in vocabulary size and composition across children and hence be useful as dependent variables in correlational research, neither may be ideal for estimating the absolute proportion of nouns in children's vocabularies. The implication is that questions which rely on information about the absolute proportion of particular kinds of words in children's vocabularies can only be properly addressed by detailed longitudinal studies in which an attempt is made to collect more comprehensive vocabulary records for individual children.
  • Poletiek, F. H. (1996). Paradoxes of falsification. Quarterly Journal of Experimental Psychology Section A: Human Experimental Psychology, 49(2), 447-462. doi:10.1080/713755628.
  • Praamstra, P., Meyer, A. S., Cools, A. R., Horstink, M. W. I. M., & Stegeman, D. F. (1996). Movement preparation in Parkinson's disease: Time course and distribution of movement-related potentials in a movement precueing task. Brain, 119, 1689-1704. doi:10.1093/brain/119.5.1689.

    Abstract

    Investigations of the effects of advance information on movement preparation in Parkinson's disease using reaction time (RT) measures have yielded contradictory results. In order to obtain direct information regarding the time course of movement preparation, we combined RT measurements in a movement precueing task with multi-channel recordings of movement-related potentials in the present study. Movements of the index and middle fingers of the left and right hand were either precued or not by advance information regarding the side (left or right hand) of the required response. Reaction times were slower for patients than for control subjects. Both groups benefited equally from informative precues, indicating that patients utilized the advance information as effectively as control subjects. Lateralization of the movement-preceding cerebral activity [i.e. the lateralized readiness potential (LRP)] confirmed that patients used the available partial information to prepare their responses and started this process no later than controls. In conjunction with EMG onset times, the LRP onset measures allowed for a fractionation of the RTs, which provided clues to the stages where the slowness of Parkinson's disease patients might arise. No definite abnormalities of temporal parameters were found, but differences in the distribution of the lateralized movement-preceding activity between patients and controls suggested differences in the cortical organization of movement preparation. Differences in amplitude of the contingent negative variation (CNV) and differences in the way in which the CNV was modulated by the information given by the precue pointed in the same direction. A difference in amplitude of the P300 between patients and controls suggested that preprogramming a response required more effort from. patients than from control subjects.
  • Praamstra, P., Meyer, A. S., & Levelt, W. J. M. (1994). Neurophysiological manifestations of auditory phonological processing: Latency variation of a negative ERP component timelocked to phonological mismatch. Journal of Cognitive Neuroscience, 6(3), 204-219. doi:10.1162/jocn.1994.6.3.204.

    Abstract

    Two experiments examined phonological priming effects on reaction times, error rates, and event-related brain potential (ERP) measures in an auditory lexical decision task. In Experiment 1 related prime-target pairs rhymed, and in Experiment 2 they alliterated (i.e., shared the consonantal onset and vowel). Event-related potentials were recorded in a delayed response task. Reaction times and error rates were obtained both for the delayed and an immediate response task. The behavioral data of Experiment 1 provided evidence for phonological facilitation of word, but not of nonword decisions. The brain potentials were more negative to unrelated than to rhyming word-word pairs between 450 and 700 msec after target onset. This negative enhancement was not present for word-nonword pairs. Thus, the ERP results match the behavioral data. The behavioral data of Experiment 2 provided no evidence for phonological Facilitation. However, between 250 and 450 msec after target onset, i.e., considerably earlier than in Experiment 1, brain potentials were more negative for unrelated than for alliterating word and word-nonword pairs. It is argued that the ERP effects in the two experiments could be modulations of the same underlying component, possibly the N400. The difference in the timing of the effects is likely to be due to the fact that the shared segments in related stimulus pairs appeared in different word positions in the two experiments.
  • Radeau, M., & Van Berkum, J. J. A. (1996). Gender decision. Language and Cognitive Processes, 11(6), 605-610. doi:10.1080/016909696387006.

    Abstract

    In languages in which nouns have a grammatical gender, word recognition can be estimated by gender decision response times. Although gender decision has yet to be used extensively, it has proved sensitive to several factors that have been shown to affect lexical access. The task is not restricted to spoken language but can be used with linguistic information from other sensory modalities.
  • Roelofs, A., Meyer, A. S., & Levelt, W. J. M. (1996). Interaction between semantic and orthographic factors in conceptually driven naming: Comment on Starreveld and La Heij (1995). Journal of Experimental Psychology: Learning, Memory, and Cognition, 22, 246-251.

    Abstract

    P. A. Starreveld and W. La Heij (1995) tested the seriality view of lexical access in speech production, according to which lexical selection and the encoding of a word's form proceed in serial order without feedback. In 2 experiments, they looked at the combined effect of semantic and orthographic relatedness of written distracter words in tasks that required conceptually driven naming. They found an interaction between semantic relatedness and orthographic relatedness and argued that the observed interaction refutes the seriality view of lexical access. In this comment, the authors argue that Starreveld and La Heij's rejection of serial access was based on an oversimplified conception of the seriality view and that interaction, rather than additivity, is predicted by existing conceptions of serial access.
  • De Ruiter, J. P., & Wilkins, D. (Eds.). (1996). Max Planck Institute for Psycholinguistics: Annual report 1996. Nijmegen: Max Planck Institute for Psycholinguistics.
  • Schiller, N. O., Meyer, A. S., Baayen, R. H., & Levelt, W. J. M. (1996). A comparison of lexeme and speech syllables in Dutch. Journal of Quantitative Linguistics, 3(1), 8-28.

    Abstract

    The CELEX lexical database includes a list of Dutch syllables and their frequencies, based on syllabification of isolated word forms. In connected speech, however, sentence-level phonological rules can modify the syllables and their token frequencies. In order to estimate the changes syllables may undergo in connected speech, an empirical investigation was carried out. A large Dutch text corpus (TROUW) was transcribed, processed by word level rules, and syllabified. The resulting lexeme syllables were evaluated by comparing them to the CELEX lexical database for Dutch. Then additional phonological sentence-level rules were applied to the TROUW corpus, and the frequencies of the resulting connected speech syllables were compared with those of the lexeme syllables from TROUW. The overall correlation between lexeme and speech syllables was very high. However, speech syllables generally had more complex CV structures than lexeme syllables. Implications of the results for research involving syllables are discussed. With respect to the notion of a mental syllabary (a store for precompiled articulatory programs for syllables, see Levelt & Wheeldon, 1994) this study revealed an interesting statistical result. The calculation of the cumulative syllable frequencies showed that 85% of the syllable tokens in Dutch can be covered by the 500 most frequent syllable types, which makes the idea of a syllabary very attractive.
  • Schiller, N. O., & Köster, O. (1996). Evaluation of a foreign speaker in forensic phonetics: A report. Forensic Linguistics: The international Journal of Speech, Language and the Law, 3, 176-185.
  • Senft, G. (1994). Audio-visual equipment in research on space: Paper presented at the Multidisciplinair Symposium BEELD IN ONDERZOEK ONDERZOEK IN BEELD 26 & 27 Mei 1994 Rijksmuseum voor Volkenkunde, Leiden. Nijmegen: Mimeo.
  • Senft, G. (1994). Darum gehet hin und lehret alle Völker: Mission, Kultur- und Sprachwandel am Beispiel der Trobriand-Insulaner von Papua-Neuguinea. In P. Stüben (Ed.), Seelenfischer: Mission, Stammesvölker und Ökologie (pp. 71-91). Gießen: Focus.
  • Senft, G. (1994). Ein Vorschlag, wie man standardisiert Daten zum Thema 'Sprache, Kognition und Konzepte des Raumes' in verschiedenen Kulturen erheben kann. Linguistische Berichte, 154, 413-429.
  • Senft, G. (1996). Classificatory particles in Kilivila. New York: Oxford University Press.
  • Senft, G. (1996). [Review of the book Comparative Austronesian dictionary: An introduction to Austronesian studies ed. by Darrell T. Tryon]. Linguistics, 34, 1255-1270.
  • Senft, G. (1996). [Review of the book Language contact and change in the Austronesian world ed. by Tom Dutton and Darrell T. Tryon]. Linguistics, 34, 424-430.
  • Senft, G. (1994). [Review of the book Language, culture and society: An introduction by Zdenek Salzmann]. Man, 29, 756-757.
  • Senft, G. (1996). [Review of the book Topics in the description of Kiriwina by Ralph Lawton; ed. by Malcolm Ross and Janet Ezard]. Language and Linguistics in Melanesia, 27, 189-196.
  • Senft, G. (1996). [Review of the journal Bulletin of the International String Figure Association, Vol. 1, 1994]. Journal of the Royal Anthropological Institute, 2, 363-364.
  • Senft, G. (1994). Grammaticalisation of body-part terms in Kilivila. Language and Linguistics in Melanesia, 25, 98-99.
  • Senft, G. (1996). Past is present - Present is past: Time and the harvest rituals on the Trobriand Islands. Anthropos, 91, 381-389.
  • Senft, G. (1996). Phatic communion. In J. Verschueren, J.-O. Östman, & J. Blommaert (Eds.), Handbook of Pragmatics (loose leaf installment) (loose leaf installment, 1995). Amsterdam: John Benjamins.
  • Senft, G. (1994). Spatial reference in Kilivila: The Tinkertoy Matching Games - A case study. Language and Linguistics in Melanesia, 25, 55-93.
  • Senft, G. (1994). These 'Procrustean' feelings: Some of my problems in describing Kilivila. Semaian, 11, 86-105.
  • Seuren, P. A. M. (1996). Berbice Nederlands: Een zeldzame Nederlandse creolentaal. Nederlandse Taalkunde, 1(2), 155-164.
  • Seuren, P. A. M. (1994). Categorial presupposition. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 2) (pp. 477-478). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Accommodation and presupposition. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 1) (pp. 15-16). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Denotation in discourse semantics. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 2) (pp. 859-860). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Donkey sentences. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 2) (pp. 1059-1060). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Discourse domain. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 2) (pp. 964-965). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Discourse semantics. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 2) (pp. 982-993). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). [Review of the Dictionary of St. Lucian Creole, part 1: Kweyol- English', part 2: English-Kweyol compiled by Jones E. Mondesir and ed. by Lawrence D. Carrington]. Linguistics, 32(1), 157-158. doi:10.1515/ling.1991.29.4.719.
  • Seuren, P. A. M. (1994). Factivity. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 3) (pp. 1205). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Function, set-theoretical. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 3) (pp. 1314). Oxford: Pergamon Press.
  • Seuren, P. A. M., & Bronzwaer, W. J. M. (1994). Ik besta, dus ik lieg of de grenzen van de taal: Opmaat tot een debat. Nijmegen: Faculteit der Letteren, Katholieke Universiteit Nijmegen.
  • Seuren, P. A. M. (1994). Incrementation. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 3) (pp. 1646). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Lexical conditions. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 4) (pp. 2140-2141). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Existence predicate (discourse semantics). In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 3) (pp. 1190-1191). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Existential presupposition. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 3) (pp. 1191-1192). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1996). Parameters van variatie. In R. Van Hout, & J. Kruijsen (Eds.), Taalvariaties: Toonzettingen en modulaties op een thema (pp. 211-221). Dordrecht: Foris.
  • Seuren, P. A. M. (1994). Presupposition. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 6) (pp. 3311-3320). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Projection problem. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 6) (pp. 3358-3360). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). The computational lexicon: All lexical content is predicate. In Z. Yusoff (Ed.), Proceedings of the International Conference on Linguistic Applications 26-28 July 1994 (pp. 211-216). Penang: Universiti Sains Malaysia, Unit Terjemahan Melalui Komputer (UTMK).
  • Seuren, P. A. M. (1996). Semantic syntax. Oxford: Blackwell.
  • Seuren, P. A. M. (1994). Sign. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 7) (pp. 3885-3888). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Soaps and serials. Journal of Pidgin and Creole Languages, 9(1), 131-149. doi:10.1075/jpcl.9.1.18seu.
  • Seuren, P. A. M. (1994). Syntax and semantics: Relationship. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 8) (pp. 4494-4500). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1994). Prediction and retrodiction. In R. E. Asher, & J. M. Y. Simpson (Eds.), The Encyclopedia of Language and Linguistics (vol. 6) (pp. 3302-3303). Oxford: Pergamon Press.
  • Seuren, P. A. M. (1996). What a universal semantic interlingua can do. In A. Zamulin (Ed.), Perspectives of System Informatics. Proceedings of the Andrei Ershov Second International Memorial Conference, Novosibirsk, Akademgorodok, June 25-28,1996 (pp. 41-42). Novosibirsk: A.P. Ershov Institute of Informatics Systems.
  • Seuren, P. A. M. (1994). Translation relations in semantic syntax. In G. Bouma, & G. Van Noord (Eds.), CLIN IV: Papers from the Fourth CLIN Meeting (pp. 149-162). Groningen: Vakgroep Alfa-informatica, Rijksuniversiteit Groningen.
  • Skiba, R., Ross, E., & Kern, F. (1996). Facharbeiter und Fremdsprachen: Fremdsprachenbedarf und Fremdsprachennutzung in technischen Arbeitsfeldern: eine qualitative Untersuchung. Bielefeld: Bertelsmann.
  • De Smedt, K., & Kempen, G. (1996). Discontinuous constituency in Segment Grammar. In H. C. Bunt, & A. Van Horck (Eds.), Discontinuous constituency (pp. 141-163). Berlin: Mouton de Gruyter.
  • Stolz, C. (1996). Bloxes: an interactive task for the elicitation of dimensional expressions. In S. C. Levinson (Ed.), Manual for the 1996 Field Season (pp. 25-31). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.3003352.

    Abstract

    “Dimensional expressions” single out and describe one symmetric axis of a 1D, 2D, or 3D object (e.g., The road is long). “Bloxes” is an interactive, object-matching task that elicits descriptions of dimensional contrasts between simple geometrical objects (rectangular blocks, rectangular boxes, and cylinders). The aim is to explore the linguistic encoding of dimensions, focusing on features of axis, orientation, flatness/solidity, size and shape. See also 'Suggestions for field research on dimensional expressions' (https://doi.org/10.17617/2.3003382).
  • Stolz, C. (1996). Suggestions for field research on dimensional expressions. In S. C. Levinson (Ed.), Manual for the 1996 Field Season (pp. 32-45). Nijmegen: Max Planck Institute for Psycholinguistics. doi:10.17617/2.3003382.

    Abstract

    The aim of this task is to explore the linguistic expression of “dimensions” — e.g., the height, width or depth — of objects in the world around us. In a dimensional expression, one symmetric axis of a 1D, 2D, or 3D object is singled out and described (e.g., That man is tall). Dimensional expressions in different languages show a range of different combinatorial and extensional uses. This document guides the researcher through some spatial situations where contrastive features of dimensional expressions are likely to be observable.
  • Suppes, P., Böttner, M., & Liang, L. (1996). Machine learning comprehension grammars for ten languages. Computational Linguistics, 22(3), 329-350.
  • Van Berkum, J. J. A. (1996). De taalpsychologie van genus. NEDER-L, Electronisch Tijdschrift voor de Neerlandistiek, (9601.a ): 9601.04.
  • Van Donselaar, W., Kuijpers, C., & Cutler, A. (1996). How do Dutch listeners process words with epenthetic schwa? In H. T. Bunnell (Ed.), Proceedings of the Fourth International Conference on Spoken Language Processing: Vol. 1 (pp. 149-152). New York: Institute of Electrical and Electronics Engineers.

    Abstract

    Dutch words with certain final consonant clusters are subject to optional schwa epenthesis. The present research aimed at investigating how Dutch listeners deal with this type of phonological variation. By means of syllable monitoring experiments, it was investigated whether Dutch listeners process words with epenthetic schwa (e.g., ’balluk’) as bisyllabic words or rather as monosyllabic words. Real words (e.g., ’balk’, ’balluk’) and pseudowords (e.g., ’golk’, ’golluk’) were compared, to examine effects of lexical representation. No difference was found between monitoring times for BAL targets in ’balluk’ carriers as compared to ’balk’ carriers. This suggests that words with epenthetic schwa are not processed as bisyllabic words. The effects for the pseudo-words paralleled those for the real words, which suggests that they are not due to lexical representation but rather to the application of phonological rules.
  • Van Valin Jr., R. D. (1994). Extraction restrictions, competing theories and the argument from the poverty of the stimulus. In S. D. Lima, R. Corrigan, & G. K. Iverson (Eds.), The reality of linguistic rules (pp. 243-259). Amsterdam: Benjamins.
  • Van Berkum, J. J. A. (1996). The psycholinguistics of grammatical gender: Studies in language comprehension and production. PhD Thesis, University of Nijmegen.
  • Van Berkum, J. J. A. (1996). The linguistics of gender. In The psycholinguistics of grammatical gender: Studies in language comprehension and production (pp. 14-44). Nijmegen University Press.

    Abstract

    This chapter explores grammatical gender as a linguistic phenomenon. First, I define gender in terms of agreement, and look at the parts of speech that can take gender agreement. Because it relates to assumptions underlying much psycholinguistic gender research, I also examine the reasons why gender systems are thought to emerge, change, and disappear. Then, I describe the gender system of Dutch. The frequent confusion about the number of genders in Dutch will be resolved by looking at the history of the system, and the role of pronominal reference therein. In addition, I report on three lexical- statistical analyses of the distribution of genders in the language. After having dealt with Dutch, I look at whether the genders of Dutch and other languages are more or less randomly assigned, or whether there is some system to it. In contrast to what many people think, regularities do indeed exist. Native speakers could in principle exploit such regularities to compute rather than memorize gender, at least in part. Although this should be taken into account as a possibility, I will also argue that it is by no means a necessary implication.
  • Weterman, M. A. J., Wilbrink, M. J. M., Janssen, I. M., Janssen, H. A. P., Berg, E. v. d., Fisher, S. E., Craig, I., & Geurts van Kessel, A. H. M. (1996). Molecular cloning of the papillary renal cell carcinoma-associated translocation (X;1)(p11;q21) breakpoint. Cytogenetic and genome research, 75(1), 2-6. doi:10.1159/000134444.

    Abstract

    A combination of Southern blot analysis on a panel of tumor-derived somatic cell hybrids and fluorescence in situ hybridization techniques was used to map YACs, cosmids and DNA markers from the Xp11.2 region relative to the X chromosome breakpoint of the renal cell carcinoma-associated t(X;1)(p11;q21). The position of the breakpoint could be determined as follows: Xcen-OATL2-DXS146-DXS255-SYP-t(X;1)-TFE 3-OATL1-Xpter. Fluorescence in situ hybridization experiments using TFE3-containing YACs and cosmids revealed split signals indicating that the corresponding DNA inserts span the breakpoint region. Subsequent Southern blot analysis showed that a 2.3-kb EcoRI fragment which is present in all TFE3 cosmids identified, hybridizes to aberrant restriction fragments in three independent t(X;1)-positive renal cell carcinoma DNAs. The breakpoints in these tumors are not the same, but map within a region of approximately 6.5 kb. Through preparative gel electrophoresis an (X;1) chimaeric 4.4-kb EcoRI fragment could be isolated which encompasses the breakpoint region present on der(X). Preliminary characterization of this fragment revealed the presence of a 150-bp region with a strong homology to the 5' end of the mouse TFE3 cDNA in the X-chromosome part, and a 48-bp segment in the chromosome 1-derived part identical to the 5' end of a known EST (accession number R93849). These observations suggest that a fusion gene is formed between the two corresponding genes in t(X;1)(p11;q21)-positive papillary renal cell carcinomas.
  • Wittenburg, P., van Kuijk, D., & Dijkstra, T. (1996). Modeling human word recognition with sequences of artificial neurons. In C. von der Malsburg, W. von Seelen, J. C. Vorbrüggen, & B. Sendhoff (Eds.), Artificial Neural Networks — ICANN 96. 1996 International Conference Bochum, Germany, July 16–19, 1996 Proceedings (pp. 347-352). Berlin: Springer.

    Abstract

    A new psycholinguistically motivated and neural network based model of human word recognition is presented. In contrast to earlier models it uses real speech as input. At the word layer acoustical and temporal information is stored by sequences of connected sensory neurons which pass on sensor potentials to a word neuron. In experiments with a small lexicon which includes groups of very similar word forms, the model meets high standards with respect to word recognition and simulates a number of wellknown psycholinguistical effects.

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