Displaying 1 - 33 of 33
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Alagöz, G., Molz, B., Eising, E., Schijven, D., Francks, C., Stein, J. L., & Fisher, S. E. (2022). Using neuroimaging genomics to investigate the evolution of human brain structure. Poster presented at the Reconstructing the human past: Using ancient and modern genomics symposium (EMBL), Heidelberg, Germany.
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Amelink, J., Postema, M., Kong, X., Sha, Z., Schijven, D., Molz, B., Joliot, M., Fisher, S. E., & Francks, C. (2022). Genetic correlates of intra- and interhemispheric resting state functional language connectivity. Poster presented at the IMPRS Conference 2022, Nijmegen, the Netherlands.
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Amelink, J., Postema, M., Kong, X., Sha, Z., Schijven, D., Molz, B., Joliot, M., Fisher, S. E., & Francks, C. (2022). Genetic correlates of intra- and interhemispheric resting state functional language connectivity. Talk presented at the Neuromatch Conference (NMC 2022). online. 2022-09-27 - 2022-09-28.
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Francks, C. (2022). Genetics of human brain asymmetry [invited talk]. Talk presented at the FENS Forum 2022 miniconference: Understanding Behaviour: Molecular, Cellular & Systems Approaches. Paris, France. 2022-07-09.
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Francks, C. (2022). Imaging genomics group at the Max Planck Institute Nijmegen [invited talk]. Talk presented at the Neurodevelopmental Disorders Principal Investigator meeting, Radboud University Medical Center. Nijmegen, The Netherlands. 2022-04-19.
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Francks, C. (2022). Imaging genomics of left-right asymmetry in the human brain [invited talk]. Talk presented at the Donders Institute research theme 3 meeting. Nijmegen, The Netherlands. 2022-05-19.
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Francks, C. (2022). Mapping the brain: Neuroimaging and connectome approaches to study genetic variation in brain function, structure, and behavior [symposium chair]. Talk presented at the Annual Meeting of International Behavioural and Neural Genetics Society. Memphis, TN, USA. 2022-05-24 - 2022-05-27.
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Francks, C. (2022). Multi-level integrative analysis of brain lateralization for language. Talk presented at the Human Brain Project EBRAINS workshop. Berg en Dal, The Netherlands. 2022-09-05 - 2022-09-07.
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Francks, C. (2022). Human brain and behavioural asymmetries: Genetic influences and associations with psychiatric disorders [keynote]. Talk presented at the Aphasia Junior days. Nijmegen, The Netherlands. 2022-12-13 - 2022-12-14.
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Gunz, P., Molz, B., Eising, E., Alagöz, G., Schijven, D., Francks, C., & Fisher, S. E. (2022). Scratching the surface: The genetic bases of brain globularity. Talk presented at the European Society for the study of Human Evolution meeting (ESHE 2022). Tübingen, Germany. 2022-09-21 - 2022-09-25.
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Molz, B., Gunz, P., Eising, E., Alagöz, G., Schijven, D., Francks, C., & Fisher, S. E. (2022). Deciphering the underlying biological mechanisms of modern human brain shape. Talk presented at the IMPRS Conference 2022. Nijmegen, the Netherlands. 2022-06-01 - 2022-06-03.
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Molz, B., Gunz, P., Eising, E., Alagöz, G., Schijven, D., Francks, C., & Fisher, S. E. (2022). Insights into the biological bases of modern human brain shape. Poster presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022), Glasgow, Scotland.
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Schijven, D., Postema, M., ENIGMA-Schizophrenia Working Group, Fisher, S. E., Franke, B., Glahn, D. C., Gur, R. C., Hashimoto, R., Jahanshad, N., Luders, E., Medland, S. E., Thompson, P. M., Turner, J. A., Van Erp, T. G. M., & Francks, C. (2022). Large-scale analysis of brain structural asymmetries in schizophrenia via the ENIGMA Consortium. Poster presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022), Glasgow, Scotland.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Talk presented at the Annual Meeting of International Behavioural and Neural Genetics Society. Memphis, TN, USA. 2022-05-24 - 2022-05-27.
Abstract
White matter tracts form the structural basis of large-scale functional networks in the human brain. We applied brain-wide tractography to diffusion images from 30,810 adult participants (UK Biobank), and found significant heritability for 90 regional connectivity measures and 851 fiber tracts. Multivariate genome-wide association analyses identified 355 independently associated lead SNPs across the genome, of which 77% were not previously associated with human brain metrics. Enrichment analyses implicated neurodevelopmental processes including neurogenesis, neural differentiation, neural migration, neural projection guidance, and axon development, as well as prenatal brain expression especially in stem cells, astrocytes, microglia and neurons. We used the multivariate association profiles of lead SNPs to identify 26 genomic loci implicated in structural connectivity between core regions of the left-hemisphere language network, and also identified 6 loci associated with hemispheric left-right asymmetry of structural connectivity. Polygenic scores for schizophrenia, bipolar disorder, autism spectrum disorder, attention-deficit hyperactivity disorder, reading ability, left-handedness, Alzheimer’s disease, amyotrophic lateral sclerosis, and epilepsy showed significant multivariate associations with structural connectivity, each implicating specific sets of brain regions with trait-relevant functional profiles. This large-scale mapping study revealed common genetic contributions to the human brain's structural connectome in the general adult population, and its links with polygenic disposition to brain disorders and behavioral traits. -
Sha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J. and 38 moreSha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J., Fitzgerald, J., Floris, D. L., Franke, B., Freitag, C. M., Gallagher, L., Glahn, D. C., Haar, S., Hoekstra, L., Jahanshad, N., Jalbrzikowski, M., Janssen, J., King, J. A., Lazaro, L., Luna, B., McGrath, J., Medland, S. E., Muratori, F., Murphy, D. G., Neufeld, J., O’Hearn, K., Oranje, B., Parellada, M., Pariente, J. C., Postema, M., Remnelius, K. L., Retico, A., Rosa, P. G. P., Rubia, K., Shook, D., Tammimies, K., Taylor, M. J., Tosetti, M., Wallace, G. L., Zhou, F., Thompson, P. M., Fisher, S. E., Buitelaar, J. K., & Francks, C. (2022). Subtly altered topological asymmetry of brain structural covariance networks in autism. Poster presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022), Glasgow, Scotland.
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Sha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J. and 38 moreSha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J., Fitzgerald, J., Floris, D. L., Franke, B., Freitag, C. M., Gallagher, L., Glahn, D. C., Haar, S., Hoekstra, L., Jahanshad, N., Jalbrzikowski, M., Janssen, J., King, J. A., Lazaro, L., Luna, B., McGrath, J., Medland, S. E., Muratori, F., Murphy, D. G., Neufeld, J., O’Hearn, K., Oranje, B., Parellada, M., Pariente, J. C., Postema, M., Remnelius, K. L., Retico, A., Rosa, P. G. P., Rubia, K., Shook, D., Tammimies, K., Taylor, M. J., Tosetti, M., Wallace, G. L., Zhou, F., Thompson, P. M., Fisher, S. E., Buitelaar, J. K., & Francks, C. (2022). Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium. Talk presented at the 2022 Society of Biological Psychiatry (SOBP) Annual Meeting. New Orleans, USA. 2022-04-28 - 2022-04-30.
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Sha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J. and 38 moreSha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J., Fitzgerald, J., Floris, D. L., Franke, B., Freitag, C. M., Gallagher, L., Glahn, D. C., Haar, S., Hoekstra, L., Jahanshad, N., Jalbrzikowski, M., Janssen, J., King, J. A., Lazaro, L., Luna, B., McGrath, J., Medland, S. E., Muratori, F., Murphy, D. G., Neufeld, J., O’Hearn, K., Oranje, B., Parellada, M., Pariente, J. C., Postema, M., Remnelius, K. L., Retico, A., Rosa, P. G. P., Rubia, K., Shook, D., Tammimies, K., Taylor, M. J., Tosetti, M., Wallace, G. L., Zhou, F., Thompson, P. M., Fisher, S. E., Buitelaar, J. K., & Francks, C. (2022). Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium. Talk presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022). Glasgow, Scotland. 2022-06-19 - 2022-06-23.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Talk presented at the World Congress of Psychiatric Genetics (WCPG 2022). Florence, Italy. 2022-09-13 - 2022-09-17.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Poster presented at the FENS Forum 2022, Paris, France.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Talk presented at Theme Discussion (RadboudUMC). online. 2022-10-21.
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Carrion Castillo, A., Tzourio-Mazoyer, N., Kavaklioglu, T., Badillo, S., Chavent, M., Saracco, J., Fisher, S. E., Mazoyer, B., & Francks, C. (2018). Atypical lateralization for sentence production, reading, and listening: detection with multivariate clustering and search for associated rare genetic variants using whole genome sequencing. Talk presented at the International Workshop on Imaging Genetics of Human Brain Laterality. Nijmegen, The Netherlands. 2018-01-30.
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Carrion Castillo, A., Tzourio-Mazoyer, N., Kavaklioglu, T., Badillo, S., Chavent, M., Saracco, J., Fisher, S. E., Mazoyer, B., & Francks, C. (2018). Genome sequencing for rightward hemispheric language dominance. Poster presented at the 11th FENS Forum of Neuroscience (FENS 2018), Berlin, Germany.
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Carrion Castillo, A., Fisher, S. E., & Francks, C. (2018). Planum temporale asymmetry is heritable in the UK biobank (N=12,236). Poster presented at the 26th World Congress of Psychiatric Genetics 2018, Glasgow, UK.
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Eising, E., St Pourcain, B., Francks, C., Fisher, S. E., & the Quantitative Trait Working Group of the GenLang consortium (2018). A genome-wide association screen of quantitative speech, language and reading traits in >14,000 people in the GenLang consortium. Poster presented at the 26th World Congress of Psychiatric Genetics 2018, Glasgow, UK.
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Kong, X., Boedhoe, P., ENIGMA OCD Working Group, Thompson, P., Van den Heuvel, O. A., & Francks, C. (2018). A survey of altered brain anatomical asymmetry in Obsessive-Compulsive Disorder. Poster presented at the 73rdAnnual Meeting of the Society of Biological Psychiatry (SOBP 2018), New York, NY, USA.
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Kong, X., & Francks, C. (2018). Mapping brain asymmetry: Updates from the ENIGMA Lateralization Group. Talk presented at the ENIGMA Consortium Chairs Annual Retreat 2018. New York, NY, USA. 2018-05-08.
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Kong, X., Mathias, S. R., Guadalupe, T., ENIGMA Laterality Working Group, Glahn, D. C., Franke, B., Crivello, F., Tzourio-Mazoyer, N., Fisher, S. E., Thompson, P. M., & Francks, C. (2018). Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium. Poster presented at the 24th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2018), Singapore.
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Postema, M., Fisher, S. E., & Francks, C. (2018). Alterations of brain laterality in psychiatric, behavioural and developmental disorders. Talk presented at the MPI Research Progress Presentations. Nijmegen, The Netherlands. 2018-11-22.
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Postema, M., Hoogman, M., van Rooij, D., Fisher, S. E., Franke, B., Buitelaar, J. E., & Francks, C. (2018). Exploring structural brain asymmetries in various disorders through the ENIGMA consortium. Talk presented at the MPI Proudly Presents series. Nijmegen, The Netherlands. 2018-06-20.
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Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Talk presented at the 6th North Sea Laterality International Meeting 2018. Dundee, UK. 2018-08-22 - 2018-08-24.
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Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Poster presented at the Donders Poster Sessions 2018, Nijmegen, The Netherlands.
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Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoeds, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Poster presented at the American Society of Human Genetics 68th Annual Meeting (ASHG 2018), San Diego, CA, USA.
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Postema, M., Carrion Castillo, A., Fisher, S. E., Vingerhoets, G., & Francks, C. (2018). The genetics of situs inversus totalis without primary ciliary dyskinesia. Talk presented at the MPI workshop "Imaging Genetics of Human Brain Laterality". Nijmegen, The Netherlands. 2018-01-30.
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