Displaying 1 - 28 of 28
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Alagöz, G., Molz, B., Eising, E., Schijven, D., Francks, C., Stein, J. L., & Fisher, S. E. (2022). Using neuroimaging genomics to investigate the evolution of human brain structure. Poster presented at the Reconstructing the human past: Using ancient and modern genomics symposium (EMBL), Heidelberg, Germany.
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Amelink, J., Postema, M., Kong, X., Sha, Z., Schijven, D., Molz, B., Joliot, M., Fisher, S. E., & Francks, C. (2022). Genetic correlates of intra- and interhemispheric resting state functional language connectivity. Poster presented at the IMPRS Conference 2022, Nijmegen, the Netherlands.
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Amelink, J., Postema, M., Kong, X., Sha, Z., Schijven, D., Molz, B., Joliot, M., Fisher, S. E., & Francks, C. (2022). Genetic correlates of intra- and interhemispheric resting state functional language connectivity. Talk presented at the Neuromatch Conference (NMC 2022). online. 2022-09-27 - 2022-09-28.
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Francks, C. (2022). Genetics of human brain asymmetry [invited talk]. Talk presented at the FENS Forum 2022 miniconference: Understanding Behaviour: Molecular, Cellular & Systems Approaches. Paris, France. 2022-07-09.
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Francks, C. (2022). Imaging genomics group at the Max Planck Institute Nijmegen [invited talk]. Talk presented at the Neurodevelopmental Disorders Principal Investigator meeting, Radboud University Medical Center. Nijmegen, The Netherlands. 2022-04-19.
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Francks, C. (2022). Imaging genomics of left-right asymmetry in the human brain [invited talk]. Talk presented at the Donders Institute research theme 3 meeting. Nijmegen, The Netherlands. 2022-05-19.
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Francks, C. (2022). Mapping the brain: Neuroimaging and connectome approaches to study genetic variation in brain function, structure, and behavior [symposium chair]. Talk presented at the Annual Meeting of International Behavioural and Neural Genetics Society. Memphis, TN, USA. 2022-05-24 - 2022-05-27.
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Francks, C. (2022). Multi-level integrative analysis of brain lateralization for language. Talk presented at the Human Brain Project EBRAINS workshop. Berg en Dal, The Netherlands. 2022-09-05 - 2022-09-07.
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Francks, C. (2022). Human brain and behavioural asymmetries: Genetic influences and associations with psychiatric disorders [keynote]. Talk presented at the Aphasia Junior days. Nijmegen, The Netherlands. 2022-12-13 - 2022-12-14.
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Gunz, P., Molz, B., Eising, E., Alagöz, G., Schijven, D., Francks, C., & Fisher, S. E. (2022). Scratching the surface: The genetic bases of brain globularity. Talk presented at the European Society for the study of Human Evolution meeting (ESHE 2022). Tübingen, Germany. 2022-09-21 - 2022-09-25.
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Molz, B., Gunz, P., Eising, E., Alagöz, G., Schijven, D., Francks, C., & Fisher, S. E. (2022). Deciphering the underlying biological mechanisms of modern human brain shape. Talk presented at the IMPRS Conference 2022. Nijmegen, the Netherlands. 2022-06-01 - 2022-06-03.
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Molz, B., Gunz, P., Eising, E., Alagöz, G., Schijven, D., Francks, C., & Fisher, S. E. (2022). Insights into the biological bases of modern human brain shape. Poster presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022), Glasgow, Scotland.
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Schijven, D., Postema, M., ENIGMA-Schizophrenia Working Group, Fisher, S. E., Franke, B., Glahn, D. C., Gur, R. C., Hashimoto, R., Jahanshad, N., Luders, E., Medland, S. E., Thompson, P. M., Turner, J. A., Van Erp, T. G. M., & Francks, C. (2022). Large-scale analysis of brain structural asymmetries in schizophrenia via the ENIGMA Consortium. Poster presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022), Glasgow, Scotland.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Talk presented at the Annual Meeting of International Behavioural and Neural Genetics Society. Memphis, TN, USA. 2022-05-24 - 2022-05-27.
Abstract
White matter tracts form the structural basis of large-scale functional networks in the human brain. We applied brain-wide tractography to diffusion images from 30,810 adult participants (UK Biobank), and found significant heritability for 90 regional connectivity measures and 851 fiber tracts. Multivariate genome-wide association analyses identified 355 independently associated lead SNPs across the genome, of which 77% were not previously associated with human brain metrics. Enrichment analyses implicated neurodevelopmental processes including neurogenesis, neural differentiation, neural migration, neural projection guidance, and axon development, as well as prenatal brain expression especially in stem cells, astrocytes, microglia and neurons. We used the multivariate association profiles of lead SNPs to identify 26 genomic loci implicated in structural connectivity between core regions of the left-hemisphere language network, and also identified 6 loci associated with hemispheric left-right asymmetry of structural connectivity. Polygenic scores for schizophrenia, bipolar disorder, autism spectrum disorder, attention-deficit hyperactivity disorder, reading ability, left-handedness, Alzheimer’s disease, amyotrophic lateral sclerosis, and epilepsy showed significant multivariate associations with structural connectivity, each implicating specific sets of brain regions with trait-relevant functional profiles. This large-scale mapping study revealed common genetic contributions to the human brain's structural connectome in the general adult population, and its links with polygenic disposition to brain disorders and behavioral traits. -
Sha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J. and 38 moreSha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J., Fitzgerald, J., Floris, D. L., Franke, B., Freitag, C. M., Gallagher, L., Glahn, D. C., Haar, S., Hoekstra, L., Jahanshad, N., Jalbrzikowski, M., Janssen, J., King, J. A., Lazaro, L., Luna, B., McGrath, J., Medland, S. E., Muratori, F., Murphy, D. G., Neufeld, J., O’Hearn, K., Oranje, B., Parellada, M., Pariente, J. C., Postema, M., Remnelius, K. L., Retico, A., Rosa, P. G. P., Rubia, K., Shook, D., Tammimies, K., Taylor, M. J., Tosetti, M., Wallace, G. L., Zhou, F., Thompson, P. M., Fisher, S. E., Buitelaar, J. K., & Francks, C. (2022). Subtly altered topological asymmetry of brain structural covariance networks in autism. Poster presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022), Glasgow, Scotland.
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Sha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J. and 38 moreSha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J., Fitzgerald, J., Floris, D. L., Franke, B., Freitag, C. M., Gallagher, L., Glahn, D. C., Haar, S., Hoekstra, L., Jahanshad, N., Jalbrzikowski, M., Janssen, J., King, J. A., Lazaro, L., Luna, B., McGrath, J., Medland, S. E., Muratori, F., Murphy, D. G., Neufeld, J., O’Hearn, K., Oranje, B., Parellada, M., Pariente, J. C., Postema, M., Remnelius, K. L., Retico, A., Rosa, P. G. P., Rubia, K., Shook, D., Tammimies, K., Taylor, M. J., Tosetti, M., Wallace, G. L., Zhou, F., Thompson, P. M., Fisher, S. E., Buitelaar, J. K., & Francks, C. (2022). Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium. Talk presented at the 2022 Society of Biological Psychiatry (SOBP) Annual Meeting. New Orleans, USA. 2022-04-28 - 2022-04-30.
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Sha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J. and 38 moreSha, Z., Van Rooij, D., Anagnostou, E., Arango, C., Auzias, G., Behrmann, M., Bernhardt, B., Bolte, S., Busatto, G. F., Calderoni, S., Calvo, R., Daly, E., Deruelle, C., Duan, M., Duran, F. L. S., Durston, S., Ecker, C., Ehrlich, S., Fair, D., Fedor, J., Fitzgerald, J., Floris, D. L., Franke, B., Freitag, C. M., Gallagher, L., Glahn, D. C., Haar, S., Hoekstra, L., Jahanshad, N., Jalbrzikowski, M., Janssen, J., King, J. A., Lazaro, L., Luna, B., McGrath, J., Medland, S. E., Muratori, F., Murphy, D. G., Neufeld, J., O’Hearn, K., Oranje, B., Parellada, M., Pariente, J. C., Postema, M., Remnelius, K. L., Retico, A., Rosa, P. G. P., Rubia, K., Shook, D., Tammimies, K., Taylor, M. J., Tosetti, M., Wallace, G. L., Zhou, F., Thompson, P. M., Fisher, S. E., Buitelaar, J. K., & Francks, C. (2022). Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium. Talk presented at the 28th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2022). Glasgow, Scotland. 2022-06-19 - 2022-06-23.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Talk presented at the World Congress of Psychiatric Genetics (WCPG 2022). Florence, Italy. 2022-09-13 - 2022-09-17.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Poster presented at the FENS Forum 2022, Paris, France.
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Sha, Z., Schijven, D., Fisher, S. E., & Francks, C. (2022). Genetic architecture of the white matter connectome of the human brain. Talk presented at Theme Discussion (RadboudUMC). online. 2022-10-21.
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Eising, E., St Pourcain, B., Francks, C., Fisher, S. E., & the Quantitative Trait Working Group of the GenLang consortium (2019). A genome-wide association screen of quantitative www.genlang.org speech, language and reading traits in >18,000 people in the GenLang consortium. Poster presented at Cognomics conference, Nijmegen.
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Eising, E., St Pourcain, B., Francks, C., & Fisher, S. E. (2020). A GWAS meta-analysis of quantitative reading and language traits in >33,000 people in the GenLang consortium. Poster presented at the World Congress of Psychiatric Genetics (WCPG 2020), online.
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Kong, X., Postema, M., Carrion Castillo, A., Pepe, A., Crivello, F., Joliot, M., Mazoyer, B., Fisher, S. E., & Francks, C. (2020). Handedness and other variables associated with human brain asymmetrical skew. Poster presented at the 26th Annual Meeting of the Organization for Human Brain Mapping (OHBM 2020), online.
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Postema, M., Hoogman, M., ENIGMA ADHD Working Group, Glahn, D. C., Jahanshad, N., Medland, S. E., Thompson, P. M., Fisher, S. E., Franke, B., & Francks, C. (2020). An ENIGMA consortium analysis of structural brain asymmetries in Attention-Deficit / Hyperactivity Disorder. Poster presented at the 2020 Society of Biological Psychiatry (SOBP) Annual Meeting, online.
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Postema, M., Pepe, A., Carrion Castillo, A., Schijven, D., Kong, X., Tzourio-Mazoyer, N., Crivello, F., Mazoyer, B., Fisher, S. E., Joliot, M., & Francks, C. (2020). Genetic influences on left-right asymmetry of functional connectivity in the human brain. Poster presented at the IMPRS conference 2020, online.
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Sha, Z., Schijven, D., Carrion Castillo, A., Joliot, M., Mazoyer, B., Fisher, S. E., Crivello, F., & Francks, C. (2020). The genetic architecture of structural left-right asymmetry of the human brain. Poster presented at the World Congress of Psychiatric Genetics (WCPG 2020), online.
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Sha, Z., Schijven, D., Carrion Castillo, A., Joliot, M., Mazoyer, B., Fisher, S. E., Crivello, F., & Francks, C. (2020). The genetic architecture of structural left-right asymmetry of the human brain. Poster presented at the Neurogenetics Conference, online.
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Sha, Z., Schijven, D., Carrion Castillo, A., Joliot, M., Mazoyer, B., Fisher, S. E., Crivello, F., & Francks, C. (2020). The genetic architecture of structural left-right asymmetry of the human brain. Talk presented at the North Sea Meeting on Laterality. online. 2020-08-27.
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