Publications

Abstract

Previous studies have demonstrated that context manipulations by semantic blocking and category priming can, under particular design conditions, give rise to semantic facilitation effects. The interpretation of semantic facilitation effects is controversial in the word production literature; perceptual accounts propose that contextually facilitated object recognition may underlie facilitation effects. The present study tested this notion. We investigated the difficulty of object recognition in a semantic blocking and a category priming task. We presented all pictures in gradually de-blurring image sequences and measured the de-blurring level that first allowed for correct object naming as an indicator of the perceptual demands of object recognition. Based on object recognition models assuming a temporal progression from coarse- to fine-grained visual processing, we reasoned that the lower the required level of detail, the more efficient the recognition processes. The results demonstrate that categorically related contexts reduce the level of visual detail required for object naming compared to unrelated contexts, with this effect being most pronounced for shape-distinctive objects and in contexts providing explicit category cues. We propose a top-down explanation based on target predictability of the observed effects. Implications of the recognition effects based on target predictability for the interpretation of context effects observed in latencies are discussed.

Abstract

This study examines how lexical frequency and planning problems can predict phonetic variability in the function word ‘the’ in conversational speech produced by non-native speakers of English. We examined 3180 tokens of ‘the’ drawn from English conversations between native speakers of Czech or Norwegian. Using regression models, we investigated the effect of following word frequency and disfluencies on three phonetic parameters: vowel duration, vowel quality, and consonant quality. Overall, the non-native speakers showed variation that is very similar to the variation displayed by native speakers of English. Like native speakers, Czech speakers showed an effect of frequency on vowel durations, which were shorter in more frequent word sequences. Both groups of speakers showed an effect of frequency on consonant quality: the substitution of another consonant for /ð/ occurred more often in the context of more frequent words. The speakers in this study also showed a native-like allophonic distinction in vowel quality, in which /ði/ occurs more often before vowels and /ðə/ before consonants. Vowel durations were longer in the presence of following disfluencies, again mirroring patterns in native speakers, and the consonant quality was more likely to be the target /ð/ before disfluencies, as opposed to a different consonant. The fact that non-native speakers show native-like sensitivity to lexical frequency and disfluencies suggests that these effects are consequences of a general, non-language-specific production mechanism governing language planning. On the other hand, the non-native speakers in this study did not show native-like patterns of vowel quality in the presence of disfluencies, suggesting that the pattern attested in native speakers of English may result from language-specific processes separate from the general production mechanisms

Abstract

How environmental factors shape patterns of biotic diversity in tropical ecosystems is an active field of research, but studies examining the possibility of ecological speciation in terrestrial tropical ecosystems are scarce. We use the isolated rainforest herpetofauna on the Montagne d'Ambre (Amber Mountain) massif in northern Madagascar as a model to explore elevational divergence at the level of populations and communities. Based on intensive sampling and DNA barcoding of amphibians and reptiles along a transect ranging from ca. 470–1470 m above sea level (a.s.l.), we assessed a main peak in species richness at an elevation of ca. 1000 m a.s.l. with 41 species. The proportion of local endemics was highest (about 1/3) at elevations >1100 m a.s.l. Two species of chameleons (Brookesia tuberculata, Calumma linotum) and two species of frogs (Mantidactylus bellyi, M. ambony) studied in depth by newly developed microsatellite markers showed genetic divergence up the slope of the mountain, some quite strong, others very weak, but in each case with genetic breaks between 1100 and 1270 m a.s.l. Genetic clusters were found in transect sections significantly differing in bioclimate and herpetological community composition. A decrease in body size was detected in several species with increasing elevation. The studied rainforest amphibians and reptiles show concordant population genetic differentiation across elevation along with morphological and niche differentiation. Whether this parapatric or microallopatric differentiation will suffice for the completion of speciation is, however, unclear, and available phylogeographic evidence rather suggests that a complex interplay between ecological and allopatric divergence processes is involved in generating the extraordinary species diversity of Madagascar's biota. Our study reveals concordant patterns of diversification among main elevational bands, but suggests that these adaptational processes are only part of the complex of processes leading to species formation, among which geographical isolation is probably also important.

Abstract

The Flinder Sensitive Line (FSL) is a rat strain that displays distinct behavioral and neurochemical features of major depression. Chronic selective serotonin reuptake inhibitors (SSRIs) are able to reverse these symptoms in FSL rats. It is well known that several abnormalities in the serotonergic system have been found in FSL rats, including increased 5-HT brain tissue levels and reduced 5-HT synthesis. SSRIs are known to exert (part of) their effects by desensitization of the 5-HT1A receptor and FSL rats appear to have lower 5-HT1A receptor densities compared with Flinder Resistant Line (FRL) rats. We therefore studied the sensitivity of this receptor on the sexual behavior performance in both FRL and FSL rats. First, basal sexual performance was studied after saline treatment followed by treatment of two different doses of the 5-HT1A receptor agonist ±8-OH-DPAT. Finally we measured the effect of a 5-HT1A receptor antagonist to check for specificity of the 5-HT1A receptor activation. Our results show that FSL rats have higher ejaculation frequencies compared with FRL rats which do not fit with a more depressive-like phenotype. Moreover FRL rats are more sensitive to effects of ±8-OH-DPAT upon EL and IF than FSL rats. The blunted response of FSL rats to the effects of ±8-OH-DPAT may be due to lower densities of 5-HT1A receptors.

Abstract

Left–right asymmetry is an important organizing feature of the healthy brain that may be altered in schizophrenia, but most studies have used relatively small samples and heterogeneous approaches, resulting in equivocal findings. We carried out the largest case–control study of structural brain asymmetries in schizophrenia, with MRI data from 5,080 affected individuals and 6,015 controls across 46 datasets, using a single image analysis protocol. Asymmetry indexes were calculated for global and regional cortical thickness, surface area, and subcortical volume measures. Differences of asymmetry were calculated between affected individuals and controls per dataset, and effect sizes were meta-analyzed across datasets. Small average case–control differences were observed for thickness asymmetries of the rostral anterior cingulate and the middle temporal gyrus, both driven by thinner left-hemispheric cortices in schizophrenia. Analyses of these asymmetries with respect to the use of antipsychotic medication and other clinical variables did not show any significant associations. Assessment of age- and sex-specific effects revealed a stronger average leftward asymmetry of pallidum volume between older cases and controls. Case–control differences in a multivariate context were assessed in a subset of the data (N = 2,029), which revealed that 7% of the variance across all structural asymmetries was explained by case–control status. Subtle case–control differences of brain macrostructural asymmetry may reflect differences at the molecular, cytoarchitectonic, or circuit levels that have functional relevance for the disorder. Reduced left middle temporal cortical thickness is consistent with altered left-hemisphere language network organization in schizophrenia.

Abstract

This study investigates whether age and/or hearing loss influence the perception of the emotion dimensions arousal (calm vs. aroused) and valence (positive vs. negative attitude) in conversational speech fragments. Specifically, this study focuses on the relationship between participants' ratings of affective speech and acoustic parameters known to be associated with arousal and valence (mean F0, intensity, and articulation rate). Ten normal-hearing younger and ten older adults with varying hearing loss were tested on two rating tasks. Stimuli consisted of short sentences taken from a corpus of conversational affective speech. In both rating tasks, participants estimated the value of the emotion dimension at hand using a 5-point scale. For arousal, higher intensity was generally associated with higher arousal in both age groups. Compared to younger participants, older participants rated the utterances as less aroused, and showed a smaller effect of intensity on their arousal ratings. For valence, higher mean F0 was associated with more negative ratings in both age groups. Generally, age group differences in rating affective utterances may not relate to age group differences in hearing loss, but rather to other differences between the age groups, as older participants' rating patterns were not associated with their individual hearing loss.

Abstract

We report on an fMRI syntactic priming experiment in which we measure brain activity for participants who communicate with another participant outside the scanner. We investigated whether syntactic processing during overt language production and comprehension is influenced by having a (shared) goal to communicate. Although theory suggests this is true, the nature of this influence remains unclear. Two hypotheses are tested: i. syntactic priming effects (fMRI and RT) are stronger for participants in the communicative context than for participants doing the same experiment in a non-communicative context, and ii. syntactic priming magnitude (RT) is correlated with the syntactic priming magnitude of the speaker’s communicative partner. Results showed that across conditions, participants were faster to produce sentences with repeated syntax, relative to novel syntax. This behavioral result converged with the fMRI data: we found repetition suppression effects in the left insula extending into left inferior frontal gyrus (BA 47/45), left middle temporal gyrus (BA 21), left inferior parietal cortex (BA 40), left precentral gyrus (BA 6), bilateral precuneus (BA 7), bilateral supplementary motor cortex (BA 32/8) and right insula (BA 47). We did not find support for the first hypothesis: having a communicative intention does not increase the magnitude of syntactic priming effects (either in the brain or in behavior) per se. We did find support for the second hypothesis: if speaker A is strongly/weakly primed by speaker B, then speaker B is primed by speaker A to a similar extent. We conclude that syntactic processing is influenced by being in a communicative context, and that the nature of this influence is bi-directional: speakers are influenced by each other.

Abstract

The acquisition of language and speech is uniquely human, but how genetic changes might have adapted the nervous system to this capacity is not well understood. Two human-specific amino acid substitutions in the transcription factor forkhead box P2 (FOXP2) are outstanding mechanistic candidates, as they could have been positively selected during human evolution and as FOXP2 is the sole gene to date firmly linked to speech and language development. When these two substitutions are introduced into the endogenous Foxp2 gene of mice (Foxp2hum), cortico-basal ganglia circuits are specifically affected. Here we demonstrate marked effects of this humanization of Foxp2 on learning and striatal neuroplasticity. Foxp2hum/hum mice learn stimulus–response associations faster than their WT littermates in situations in which declarative (i.e., place-based) and procedural (i.e., response-based) forms of learning could compete during transitions toward proceduralization of action sequences. Striatal districts known to be differently related to these two modes of learning are affected differently in the Foxp2hum/hum mice, as judged by measures of dopamine levels, gene expression patterns, and synaptic plasticity, including an NMDA receptor-dependent form of long-term depression. These findings raise the possibility that the humanized Foxp2 phenotype reflects a different tuning of corticostriatal systems involved in declarative and procedural learning, a capacity potentially contributing to adapting the human brain for speech and language acquisition.

Abstract

Speakers sometimes repeat syntactic structures across sentences, a phenomenon called syntactic priming. We investigated the influence of verb-bound syntactic preferences on syntactic priming effects in response choices and response latencies for German ditransitive sentences. In the response choices we found inverse preference effects: There were stronger syntactic priming effects for primes in the less preferred structure, given the syntactic preference of the prime verb. In the response latencies we found positive preference effects: There were stronger syntactic priming effects for primes in the more preferred structure, given the syntactic preference of the prime verb. These findings provide further support for the idea that syntactic processing is lexically guided.

Abstract

Frequency tagging has been successfully used to investigate selective stimulus processing in electroencephalography (EEG) or magnetoencephalography (MEG) studies. Recently, new projectors have been developed that allow for frequency tagging at higher frequencies (>60 Hz). This technique, rapid invisible frequency tagging (RIFT), provides two crucial advantages over low-frequency tagging as (i) it leaves low-frequency oscillations unperturbed, and thus open for investigation, and ii) it can render the tagging invisible, resulting in more naturalistic paradigms and a lack of participant awareness. The development of this technique has far-reaching implications as oscillations involved in cognitive processes can be investigated, and potentially manipulated, in a more naturalistic manner.

Abstract

This study investigated the impact of a speaker's gaze direction
on a listener's comprehension of discourse. Previous research
suggests that hand gestures play a role in referent allocation,
enabling listeners to better understand the discourse. The
current study aims to determine whether the speaker's gaze
direction has a similar effect on reference resolution as co-
speech gestures. Thirty native Japanese speakers participated in
the study and were assigned to one of three conditions:
congruent, incongruent, or speech-only. Participants watched
36 videos of an actor narrating a story consisting of three
sentences with two protagonists. The speaker consistently
used hand gestures to allocate one protagonist to the lower right
and the other to the lower left space, while directing her gaze to
either space of the target person (congruent), the other person
(incongruent), or no particular space (speech-only). Participants
were required to verbally answer a question about the target
protagonist involved in an accidental event as quickly as
possible. Results indicate that participants in the congruent
condition exhibited faster reaction times than those in the
incongruent condition, although the difference was not
significant. These findings suggest that the speaker's gaze
direction is not enough to facilitate a listener's comprehension
of discourse.

Abstract

Understanding Pragmatics takes an interdisciplinary approach to provide an accessible introduction to linguistic pragmatics. This book discusses how the meaning of utterances can only be understood in relation to overall cultural, social and interpersonal contexts, as well as to culture specific conventions and the speech events in which they are embedded. From a cross-linguistic and cross-cultural perspective, this book: • debates the core issues of pragmatics such as speech act theory, conversational implicature, deixis, gesture, interaction strategies, ritual communication, phatic communion, linguistic relativity, ethnography of speaking, ethnomethodology, conversation analysis, languages and social classes, and linguistic ideologies • incorporates examples from a broad variety of different languages and cultures • takes an innovative and transdisciplinary view of the field showing linguistic pragmatics has its predecessor in other disciplines such as philosophy, psychology, ethology, ethnology, sociology and the political sciences. Written by an experienced teacher and researcher, this introductory textbook is essential reading for all students studying pragmatics.

Abstract

This paper presents the complex system of classifiers in Kilivila, the language of the Trobriand Islanders of Papua New Guinea. After a brief introduction to the language and its speakers, the classifier system is briefly described with respect to the role of these formatives for the word formation of Kilivila numerals, adjectives, demonstratives and one form of an interrogative pronoun/adverb. Then the functions the classifier system fulfils with respect to concord, temporary classification, the unitizing of nominal expressions, nominalization, indication of plural, anaphoric reference as well as text and discourse coherence are discussed and illustrated. The paper ends with some language specific and cross-linguistic questions for further research.

Abstract

The auxiliary doen ‘do’ in standard Dutch is usually described as ‘dummy’ because it supposedly adds nothing substantial to the meaning of the sentence. We argue, however, that the auxiliary does have a function in the sentence, as a marker of either habitual or intentional aspect. In an online production experiment, we investigated the acceptability of the allegedly dummy auxiliary doen ‘do’. Results show that the degree of acceptability of the auxiliary doen ‘do’ is very low, even lower than the widely disapproved use of hun ‘them’ as a subject in Dutch. However, because a significant difference was found in the acceptability between the habitual and the intentional reading, we conclude that the auxiliary doen ‘do’ in Dutch cannot be dummy, i.e. semantically empty.

Abstract

This book argues that positivism, though now the dominant paradigm for both the natural and the human sciences, is intrinsically unfit for the latter. In particular, it is unfit for linguistics and cognitive science, where it is ultimately self-destructive, since it fails to account for causality, while the mind, the primary object of research of the human sciences, cannot be understood unless considered to be an autonomous causal force.　

Author Pieter Albertus Maria Seuren, who died shortly after this manuscript was finished and after a remarkable career, reviews the history of this issue since the seventeenth century. He focuses on Descartes, Leibniz, British Empiricism and Kant, arguing that neither cognition nor language can be adequately accounted for unless the mind is given its full due. This implies that a distinction must be made—following Alexius Meinong, but against Russell and Quine—between actual and virtual reality. The latter is a product of the causally active mind and a necessary ingredient for the setting up of mental models, without which neither cognition nor language can function. Mental models are coherent sets of propositions, and can be wholly or partially true or false. Positivism rules out mental models, blocking any serious semantics and thereby reducing both language and cognition to caricatures of themselves. Seuren presents a causal theory of meaning, linking up language with cognition and solving the old question of what meaning actually amounts to.

Abstract

This study is a prolegomenon to a formal theory of the natural growth of conceptual and lexical fields. Negation, in the various forms in which it occurs in language, is found to be a powerful indicator. Other than in standard logic, natural language negation selects its complement within universes of discourse that are, for practical and functional reasons, restricted in various ways and to different degrees. It is hypothesized that a system of cognitive principles drives recursive processes of universe restriction, which in turn affects logical relations within the restricted universes. This approach provides a new perspective in which to view the well-known clashes between standard logic and natural logical intuitions. Lexicalization in language, especially the morphological incorporation of negation, is limited to highly restricted universes, which explains, for example, why a dog can be said not to be a Catholic, but also not to be a non-Catholic. Cognition is taken to restrict the universe of discourse to contrary pairs, splitting up one or both of the contraries into further subuniverses as a result of further cognitive activity. It is shown how a logically sound square of opposition , expanded to a hexagon (Jacoby 1950, 1960, Sesmat 1951, Blanché 1952, 1953, 1966), is generated by a hierarchy of universe restrictions, defining the notion ‘natural’ for logical systems. The logical hexagon contains two additional vertices, one for ‘some but not all’ (the Y-type) and one for ‘either all or none’ (the U-type), and incorporates both the classic square and the Hamiltonian triangle of contraries . Some is thus considered semantically ambiguous, representing two distinct quantifiers. The pragmaticist claim that the language system contains only the standard logical ‘some perhaps all’ and that the ‘some but not all’ meaning is pragmatically derived from the use of the system is rejected. Four principles are proposed according to which negation selects a complement from the subuniverses at hand. On the basis of these principles and of the logico-cognitive system proposed, the well-known nonlexicalization not only of *nall and *nand but also of many other nonlogical cases found throughout the lexicons of languages is analyzed and explained

Abstract

Since Aristotle and the Stoa, there has been a clash, worsened by modern predicate logic, between logically defined operator meanings and natural intuitions. Pragmatics has tried to neutralize the clash by an appeal to the Gricean conversational maxims. The present study argues that the pragmatic attempt has been unsuccessful. The “softness” of the Gricean explanation fails to do justice to the robustness of the intuitions concerned, leaving the relation between the principles evoked and the observed facts opaque. Moreover, there are cases where the Gricean maxims fail to apply. A more adequate solution consists in the devising of a sound natural logic, part of the innate cognitive equipment of mankind. This account has proved successful in conjunction with a postulated cognitive mechanism in virtue of which the universe of discourse (Un) is stepwise and recursively restricted, so that the negation selects different complements according to the degree of restrictedness of Un. This mechanism explains not only the discrepancies between natural logical intuitions and known logical systems; it also accounts for certain systematic lexicalization gaps in the languages of the world. Finally, it is shown how stepwise restriction of Un produces the ontogenesis of natural predicate logic, while at the same time resolving the intuitive clashes with established logical systems that the Gricean maxims sought to explain

Abstract

In this study it is argued that scope, as a property of scope‐creating operators, is a real and important element in the semantico‐grammatical description of languages. The notion of scope is illustrated and, as far as possible, defined. A first idea is given of the ‘grammar of scope’, which defines the relation between scope in the logically structured semantic analysis (SA) of sentences on the one hand and surface structure on the other. Evidence is adduced showing that peripheral preposition phrases (PPPs) in the surface structure of sentences represent scope‐creating operators in SA, and that external datives fall into this category: they are scope‐creating PPPs. It follows that, in English and Dutch, the internal dative (I gave John a book) and the external dative (I gave a book to John) are not simple syntactic variants expressing the same meaning. Instead, internal datives are an integral part of the argument structure of the matrix predicate, whereas external datives represent scope‐creating operators in SA. In the Romance languages, the (non‐pronominal) external dative has been re‐analysed as an argument type dative, but this has not happened in English and Dutch, which have many verbs that only allow for an external dative (e.g. donate, reveal). When both datives are allowed, there are systematic semantic differences, including scope differences.

Abstract

Speech is perceived relative to the speech rate in the context. It is unclear, however, what information listeners use to compute speech rate. The present study examines whether listeners use the number of
syllables per unit time (i.e., syllable rate) as a measure of speech rate, as indexed by subsequent vowel perception. We ran two rate-normalization experiments in which participants heard duration-matched word lists that contained either monosyllabic
vs. bisyllabic words (Experiment 1), or monosyllabic vs. trisyllabic pseudowords (Experiment 2). The participants’ task was to categorize an /ɑ-aː/ continuum that followed the word lists. The monosyllabic condition was perceived as slower (i.e., fewer /aː/ responses) than the bisyllabic and
trisyllabic condition. However, no difference was observed between bisyllabic and trisyllabic contexts. Therefore, while syllable rate is used in perceiving speech rate, other factors, such as fast speech processes, mean F0, and intensity, must also influence rate normalization.

Abstract

When recognizing spoken words, listeners are confronted by variability in the speech signal caused by talker differences. Previous research has focused on segmental talker variability; less is known about how suprasegmental variability is handled. Here we investigated the use of perceptual learning to deal with between-talker differences in lexical stress. Two groups of participants heard Dutch minimal stress pairs (e.g., VOORnaam vs. voorNAAM, “first name” vs. “respectable”) spoken by two male talkers. Group 1 heard Talker 1 use only F0 to signal stress (intensity and duration values were ambiguous), while Talker 2 used only intensity (F0 and duration were ambiguous). Group 2 heard the reverse talker-cue mappings. After training, participants were tested on words from both talkers containing conflicting stress cues (“mixed items”; e.g., one spoken by Talker 1 with F0 signaling initial stress and intensity signaling final stress). We found that listeners used previously learned information about which talker used which cue to interpret the mixed items. For example, the mixed item described above tended to be interpreted as having initial stress by Group 1 but as having final stress by Group 2. This demonstrates that listeners learn how individual talkers signal stress and use that knowledge in spoken-word recognition.

Abstract

Frontal lobe organisation displays a functional gradient, with overarching processing goals located in parts anterior to more subordinate goals, processed more posteriorly. Functional specialisation for syntax and phonology within language relevant areas has been supported by meta-analyses and reviews, but never directly tested experimentally. We tested for organised functional specialisation by manipulating syntactic case and phonotactics, creating violations at the end of otherwise matched and predictable sentences. Both violations led to increased activation in expected language regions. We observe the clearest signs of a functional gradient for language processing in the medial frontal cortex, where syntactic violations activated a more anterior portion compared to the phonotactic violations. A large overlap of syntactic and phonotactic processing in the left inferior frontal gyrus (LIFG) supports the view that general structured sequence processes are located in this area. These findings are relevant for understanding how sentence processing is implemented in hierarchically organised processing steps in the frontal lobe.

Abstract

White matter tracts form the structural basis of large-scale brain networks. We applied brain-wide tractography to diffusion images from 30,810 adults (U.K. Biobank) and found significant heritability for 90 node-level and 851 edge-level network connectivity measures. Multivariate genome-wide association analyses identified 325 genetic loci, of which 80% had not been previously associated with brain metrics. Enrichment analyses implicated neurodevelopmental processes including neurogenesis, neural differentiation, neural migration, neural projection guidance, and axon development, as well as prenatal brain expression especially in stem cells, astrocytes, microglia, and neurons. The multivariate association profiles implicated 31 loci in connectivity between core regions of the left-hemisphere language network. Polygenic scores for psychiatric, neurological, and behavioral traits also showed significant multivariate associations with structural connectivity, each implicating distinct sets of brain regions with trait-relevant functional profiles. This large-scale mapping study revealed common genetic contributions to variation in the structural connectome of the human brain.

Abstract

Notch signaling in the nervous system is often regarded as a developmental pathway. However, recent studies have suggested that Notch is associated with neuronal discharges. Here, focusing on temporal lobe epilepsy, we found that Notch signaling was activated in the kainic acid (KA)-induced epilepsy model and in human epileptogenic tissues. Using an acute model of seizures, we showed that DAPT, an inhibitor of Notch, inhibited ictal activity. In contrast, pretreatment with exogenous Jagged1 to elevate Notch signaling before KA application had proconvulsant effects. In vivo, we demonstrated that the impacts of activated Notch signaling on seizures can in part be attributed to the regulatory role of Notch signaling on excitatory synaptic activity in CA1 pyramidal neurons. In vitro, we found that DAPT treatment impaired synaptic vesicle endocytosis in cultured hippocampal neurons. Taken together, our findings suggest a correlation between aberrant Notch signaling and epileptic seizures. Notch signaling is up-regulated in response to seizure activity, and its activation further promotes neuronal excitation of CA1 pyramidal neurons in acute seizures.

Abstract

We investigated the neural basis of inhibitory control during lexical selection. Participants overtly named pictures while response times (RTs) and event-related brain potentials (ERPs) were recorded. The difficulty of lexical selection was manipulated by using object and action pictures with high name agreement (few response candidates) versus low name agreement (many response candidates). To assess the involvement of inhibition, we conducted delta plot analyses of naming RTs and examined the N2 component of the ERP. We found longer mean naming RTs and a larger N2 amplitude in the low relative to the high name agreement condition. For action naming we found a negative correlation between the slopes of the slowest delta segment and the difference in N2 amplitude between the low and high name agreement conditions. The converging behavioral and electrophysiological evidence suggests that selective inhibition is engaged to reduce competition during lexical selection in picture naming.

Abstract

The present study provides Dutch norms for age of acquisition, familiarity, imageability, image agreement, visual complexity, word frequency, and word length (in syllables) for 124 line drawings of actions. Ratings were obtained from 117 Dutch participants. Word frequency was determined on the basis of the SUBTLEX-NL corpus (Keuleers, Brysbaert, & New, Behavior Research Methods, 42, 643–650, 2010). For 104 of the pictures, naming latencies and name agreement were determined in a separate naming experiment with 74 native speakers of Dutch. The Dutch norms closely corresponded to the norms for British English. Multiple regression analysis showed that age of acquisition, imageability, image agreement, visual complexity, and name agreement were significant predictors of naming latencies, whereas word frequency and word length were not. Combined with the results of a principal-component analysis, these findings suggest that variables influencing the processes of conceptual preparation and lexical selection affect latencies more strongly than do variables influencing word-form encoding.

Abstract

This study examined the contributions of verbal ability and executive control to verbal fluency performance in older adults (n=82). Verbal fluency was assessed in letter and category fluency tasks, and performance on these tasks was related to indicators of vocabulary size, lexical access speed, updating, and inhibition ability. In regression analyses the number of words produced in both fluency tasks was predicted by updating ability, and the speed of the first response was predicted by vocabulary size and, for category fluency only, lexical access speed. These results highlight the hybrid character of both fluency tasks, which may limit their usefulness for research and clinical purposes.

Abstract

Pitch is often described metaphorically: for example, Farsi and Turkish speakers use a ‘thickness’ metaphor (low sounds are ‘thick’ and high sounds are ‘thin’), while German and English speakers use a height metaphor (‘low’, ‘high’). This study examines how child and adult speakers of Farsi, Turkish, and German map pitch and thickness using a cross-modal association task. All groups, except for German children, performed significantly better than chance. German-speaking adults’ success suggests the pitch-to-thickness association can be learned by experience. But the fact that German children were at chance indicates that this learning takes time. Intriguingly, Farsi and Turkish children's performance suggests that learning cross-modal associations can be boosted through experience with consistent metaphorical mappings in the input language

Abstract

Size analysis can be an important part of heap consumption analysis. This paper is a part of ongoing work about typing support for checking output-on-input size dependencies for function definitions in a strict functional language. A significant restriction for our earlier results is that inner data structures (e.g. in a list of lists) all must have the same size. Here, we make a big step forwards by overcoming this limitation via the introduction of higher-order size annotations such that variate sizes of inner data structures can be expressed. In this way the analysis becomes applicable for general, polymorphic nested lists.

Abstract

Contrary to linear difference equations, there is no general theory of difference equations of the form G(P(x−τ1),…,P(x−τs))+G0(x)=0, with τi∈K, G(x1,…,xs)∈K[x1,…,xs] of total degree D⩾2 and G0(x)∈K[x], where K is a field of characteristic zero. This article is concerned with the following problem: given τi, G and G0, find an upper bound on the degree d of a polynomial solution P(x), if it exists. In the presented approach the problem is reduced to constructing a univariate polynomial for which d is a root. The authors formulate a sufficient condition under which such a polynomial exists. Using this condition, they give an effective bound on d, for instance, for all difference equations of the form G(P(x−a),P(x−a−1),P(x−a−2))+G0(x)=0 with quadratic G, and all difference equations of the form G(P(x),P(x−τ))+G0(x)=0 with G having an arbitrary degree.

Abstract

This paper presents research findings on manual gestures
associated with negation in Indonesian, utilizing data sourced
from talk shows available on YouTube. The study reveals that
Indonesian speakers employ six recurrent negation gestures,
which have been observed in various languages worldwide.
This suggests that gestures exhibiting a stable form-meaning
relationship and recurring frequently in relation to negation are
prevalent around the globe, although their distribution may
differ across cultures and languages. Furthermore, the paper
demonstrates that negation gestures are not strictly tied to
verbal negation. Overall, the aim of this paper is to contribute
to a deeper understanding of the conventional usage and cross-
linguistic distribution of recurrent gestures.

Abstract

We investigated global integration (wrap-up) processes at the boundaries of musical phrases by comparing the effects of well and non-well formed phrases on event-related potentials time-locked to two boundary points: the onset and the offset of the boundary pause. The Closure Positive Shift, which is elicited at the boundary offset, was not modulated by the quality of phrase structure (well vs. non-well formed). In contrast, the boundary onset potentials showed different patterns for well and non-well formed phrases. Our results contribute to specify the functional meaning of the Closure Positive Shift in music, shed light on the large-scale structural integration of musical input, and raise new hypotheses concerning shared resources between music and language.

Abstract

Neuroscientific and musicological approaches to music cognition indicate that listeners familiarized in the Western tonal tradition expect a musical phrase boundary at predictable time intervals. However, phrase boundary prediction processes in music remain untested. We analyzed event-related potentials (ERPs) and event-related induced power changes at the onset and offset of a boundary pause. We made comparisons with modified melodies, where the pause was omitted and filled by tones. The offset of the pause elicited a closure positive shift (CPS), indexing phrase boundary detection. The onset of the filling tones elicited significant increases in theta and beta powers. In addition, the P2 component was larger when the filling tones started than when they ended. The responses to boundary omission suggest that listeners expected to hear a boundary pause. Therefore, boundary prediction seems to coexist with boundary detection in music segmentation.

Abstract

Formal language hierarchy describes levels of increasing syntactic complexity (adjacent dependencies, nonadjacent nested, nonadjacent crossed) of which the transcription into a hierarchy of cognitive complexity remains under debate. The cognitive foundations of formal language hierarchy have been contradicted by two types of evidence: First, adjacent dependencies are not easier to learn compared to nonadjacent; second, crossed nonadjacent dependencies may be easier than nested. However, studies providing these findings may have engaged confounds: Repetition monitoring strategies may have accounted for participants’ high performance in nonadjacent dependencies, and linguistic experience may have accounted for the advantage of crossed dependencies. We conducted two artificial grammar learning experiments where we addressed these confounds by manipulating reliance on repetition monitoring and by testing participants inexperienced with crossed dependencies. Results showed relevant differences in learning adjacent versus nonadjacent dependencies and advantages of nested over crossed, suggesting that formal language hierarchy may indeed translate into a hierarchy of cognitive complexity

Abstract

Taboo words are emotional words which, in psycho and neurolinguistic studies, present higher attentional capture, are more memorable and complex to process.
Such phenomena are connected to dimensions such as arousal and valence, which reflect social, psychological and neurological aspects. The present study, the first of its kind in Brazilian Portuguese, aims to collect normative data in order to characterize what distinguish the processing of taboo words from other emotional words. The study crosses over to sociolinguistics by mapping linguistic attitudes towards taboo words, which are salient stylistic elements, subject to negative judgement, and strongly engage the sociolinguistic monitor. We aim to examine how certain aspects that may underlie beliefs and linguistic attitudes, such as gender, religiosity, habit of engaging in swearing, family tolerance and likelihood to take offense, modulate taboo word perception. Answers given by 164 university students from Rio de Janeiro to an explicit questionnaire about swear words were compared to less explicit judgements on 200 words in order to examine: (i) whether frequency, familiarity, valence, offensiveness, tabooness and arousal set taboo words apart from other categories (positive, negative and neutral words); (ii) the influence of participants’ sociocultural profile on such judgements, reflecting sociolinguistic monitoring. We observed that taboo words fall into a distinct category, mainly due to high social tabooness and offensiveness ratings, but also due to low familiarity and negative valence. These results confirm more negative linguistic attitudes regarding taboo words influenced by religiosity, family environment and gender, pertinent aspects to the understanding of these speakers’ linguistic identity.

Abstract

An ability to decode semantic information from fMRI spatial patterns has been demonstrated in previous studies mostly for 1 specific input modality. In this study, we aimed to decode semantic category independent of the modality in which an object was presented. Using a searchlight method, we were able to predict the stimulus category from the data while participants performed a semantic categorization task with 4 stimulus modalities (spoken and written names, photographs, and natural sounds). Significant classification performance was achieved in all 4 modalities. Modality-independent decoding was implemented by training and testing the searchlight method across modalities. This allowed the localization of those brain regions, which correctly discriminated between the categories, independent of stimulus modality. The analysis revealed large clusters of voxels in the left inferior temporal cortex and in frontal regions. These voxels also allowed category discrimination in a free recall session where subjects recalled the objects in the absence of external stimuli. The results show that semantic information can be decoded from the fMRI signal independently of the input modality and have clear implications for understanding the functional mechanisms of semantic memory.

Abstract

This study examines what stage 9‐12‐year‐old Dutch‐speaking children have reached in the development of their L2 lexicon, focusing on its phonological specificity. Two experiments were carried out with a group of Dutch‐speaking children and adults learning English. In a first task, listeners were asked to judge Dutch words which were presented with either the target Dutch vowel or with an English vowel synthetically inserted. The second experiment was a mirror of the first, i.e. with English words and English or Dutch vowels inserted. It was examined to what extent the listeners accepted substitutions of Dutch vowels by English ones, and vice versa. The results of the experiments suggest that the children have not reached the same degree of phonological specificity of L2 words as the adults. Children not only experience a strong influence of their native vowel categories when listening to L2 words, they also apply less strict criteria.

Abstract

This study investigated the phonological representations of vowels in children's native and non-native lexicons. Two experiments were mispronunciation tasks (i.e., a vowel in words was substituted by another vowel from the same language). These were carried out by Dutch-speaking 9–12-year-old children and Dutch-speaking adults, in their native (Experiment 1, Dutch) and non-native (Experiment 2, English) language. A third experiment tested vowel discrimination. In Dutch, both children and adults could accurately detect mispronunciations. In English, adults, and especially children, detected substitutions of native vowels (i.e., vowels that are present in the Dutch inventory) by non-native vowels more easily than changes in the opposite direction. Experiment 3 revealed that children could accurately discriminate most of the vowels. The results indicate that children's L1 categories strongly influenced their perception of English words. However, the data also reveal a hint of the development of L2 phoneme categories.

Abstract

Aim Sex chromosome aneuploidies increase the risk of spoken or written language disorders but individuals with specific language impairment (SLI) or dyslexia do not routinely undergo cytogenetic analysis. We assess the frequency of sex chromosome aneuploidies in individuals with language impairment or dyslexia. Method Genome-wide single nucleotide polymorphism genotyping was performed in three sample sets: a clinical cohort of individuals with speech and language deficits (87 probands: 61 males, 26 females; age range 4 to 23 years), a replication cohort of individuals with SLI, from both clinical and epidemiological samples (209 probands: 139 males, 70 females; age range 4 to 17 years), and a set of individuals with dyslexia (314 probands: 224 males, 90 females; age range 7 to 18 years). Results In the clinical language-impaired cohort, three abnormal karyotypic results were identified in probands (proband yield 3.4%). In the SLI replication cohort, six abnormalities were identified providing a consistent proband yield (2.9%). In the sample of individuals with dyslexia, two sex chromosome aneuploidies were found giving a lower proband yield of 0.6%. In total, two XYY, four XXY (Klinefelter syndrome), three XXX, one XO (Turner syndrome), and one unresolved karyotype were identified. Interpretation The frequency of sex chromosome aneuploidies within each of the three cohorts was increased over the expected population frequency (approximately 0.25%) suggesting that genetic testing may prove worthwhile for individuals with language and literacy problems and normal non-verbal IQ. Early detection of these aneuploidies can provide information and direct the appropriate management for individuals.

Abstract

While global patterns of human genetic diversity are increasingly well characterized, the diversity of human languages remains less systematically described. Here, we outline the Grambank database. With over 400,000 data points and 2400 languages, Grambank is the largest comparative grammatical database available. The comprehensiveness of Grambank allows us to quantify the relative effects of genealogical inheritance and geographic proximity on the structural diversity of the world’s languages, evaluate constraints on linguistic diversity, and identify the world’s most unusual languages. An analysis of the consequences of language loss reveals that the reduction in diversity will be strikingly uneven across the major linguistic regions of the world. Without sustained efforts to document and revitalize endangered languages, our linguistic window into human history, cognition, and culture will be seriously fragmented.

Abstract

To understand language, we need to recognize words and combine them into phrases and sentences. During this process, responses to the words themselves are changed. In a step towards understanding how the brain builds sentence structure, the present study concerns the neural readout of this adaptation. We ask whether low-frequency neural readouts associated with words change as a function of being in a sentence. To this end, we analyzed an MEG dataset by Schoffelen et al. (2019) of 102 human participants (51 women) listening to sentences and word lists, the latter lacking any syntactic structure and combinatorial meaning. Using temporal response functions and a cumulative model-fitting approach, we disentangled delta- and theta-band responses to lexical information (word frequency), from responses to sensory- and distributional variables. The results suggest that delta-band responses to words are affected by sentence context in time and space, over and above entropy and surprisal. In both conditions, the word frequency response spanned left temporal and posterior frontal areas; however, the response appeared later in word lists than in sentences. In addition, sentence context determined whether inferior frontal areas were responsive to lexical information. In the theta band, the amplitude was larger in the word list condition around 100 milliseconds in right frontal areas. We conclude that low-frequency responses to words are changed by sentential context. The results of this study speak to how the neural representation of words is affected by structural context, and as such provide insight into how the brain instantiates compositionality in language.

Abstract

The visual world paradigm is one of the most influential paradigms to study real-time language processing. The present study tested whether visual world studies can be moved online, using PCIbex software (Zehr & Schwarz, 2018) and the WebGazer.js algorithm (Papoutsaki et al., 2016) to collect eye-movement data. Experiment 1 was a fixation task in which the participants looked at a fixation cross in multiple positions on the computer screen. Experiment 2 was a web-based replication of a visual world experiment by Dijkgraaf et al. (2017). Firstly, both experiments revealed that the spatial accuracy of the data allowed us to distinguish looks across the four quadrants of the computer screen. This suggest that the spatial resolution of WebGazer.js is fine-grained enough for most visual world experiments (which typically involve a two-by-two quadrant-based set-up of the visual display). Secondly, both experiments revealed a delay of roughly 300 ms in the time course of the eye movements, possibly caused by the internal processing speed of the browser or WebGazer.js. This delay can be problematic in studying questions that require a fine-grained temporal resolution and requires further investigation.

Abstract

Language comprehension involves the derivation of the meaning of sentences by combining the meanings of their parts. In some cases, this can lead to ambiguity. A sentence like Every hiker climbed a hill allows two logical representations: One that specifies that every hiker climbed a different hill and one that specifies that every hiker climbed the same hill. The interpretations of such sentences can be primed: Exposure to a particular reading increases the likelihood that the same reading will be assigned to a subsequent similar sentence. Feiman and Snedeker (2016) observed that such priming is not modulated by overlap of the verb between prime and target. This indicates that mental logical representations specify the compositional structure of the sentence meaning without conceptual meaning content. We conducted a close replication of Feiman and Snedeker’s experiment in Dutch and found no verb-independent priming. Moreover, a comparison with a previous, within-verb priming experiment showed an interaction, suggesting stronger verb-specific than abstract priming. A power analysis revealed that both Feiman and Snedeker’s experiment and our Experiment 1 were underpowered. Therefore, we replicated our Experiment 1, using the sample size guidelines provided by our power analysis. This experiment again showed that priming was stronger if a prime-target pair contained the same verb. Together, our experiments show that logical representation priming is enhanced if the prime and target sentence contain the same verb. This suggests that logical representations specify compositional structure and meaning features in an integrated manner.

Abstract

Crosslinguistic studies of expressions of motion events have found that Talmy's binary typology of verb-framed and satellite-framed languages is reflected in language use. In particular, Manner of motion is relatively more elaborated in satellite-framed languages (e.g., in narrative, picture description, conversation, translation). The present research builds on previous controlled studies of the domain of human motion by eliciting descriptions of a wide range of manners of walking and running filmed in natural circumstances. Descriptions were elicited from speakers of two satellite-framed languages (English, Polish) and three verb-framed languages (French, Spanish, Basque). The sampling of events in this study resulted in four major semantic clusters for these five languages: walking, running, non-canonical gaits (divided into bounce-and-recoil and syncopated movements), and quadrupedal movement (crawling). Counts of verb types found a broad tendency for satellite-framed languages to show greater lexical diversity, along with substantial within group variation. Going beyond most earlier studies, we also examined extended descriptions of manner of movement, isolating types of manner. The following categories of manner were identified and compared: attitude of actor, rate, effort, posture, and motor patterns of legs and feet. Satellite-framed speakers tended to elaborate expressive manner verbs, whereas verb-framed speakers used modification to add manner to neutral motion verbs

Abstract

Cerebellar ataxias are progressive neurodegenerative disorders characterized by atrophy of the cerebellum leading to motor dysfunction, balance problems, and limb and gait ataxia. These include among others, the dominantly inherited spinocerebellar ataxias, recessive cerebellar ataxias such as Friedreich's ataxia, and X-linked cerebellar ataxias. Since all cerebellar ataxias display considerable overlap in their disease phenotypes, common pathological pathways must underlie the selective cerebellar neurodegeneration. Therefore, it is important to identify the molecular mechanisms and routes to neurodegeneration that cause cerebellar ataxia. In this review, we discuss the use of functional genomic approaches including whole-exome sequencing, genome-wide gene expression profiling, miRNA profiling, epigenetic profiling, and genetic modifier screens to reveal the underlying pathogenesis of various cerebellar ataxias. These approaches have resulted in the identification of many disease genes, modifier genes, and biomarkers correlating with specific stages of the disease. This article is part of a Special Issue entitled: From Genome to Function.

Abstract

The effect of literacy on phonological processing has been described in terms of a virus that “infects all speech processing” (Frith, 1998). Empirical data has established that literacy leads to changes to the way in which phonological information is processed. Harm & Seidenberg (1999) demonstrated that a connectionist network trained to map between English orthographic and phonological representations display’s more componential phonological processing than a network trained only to stably represent the phonological forms of words. Within this study we use a similar model yet manipulate the transparency of orthographic-to-phonological mappings. We observe that networks trained on a transparent orthography are better at restoring phonetic features and phonemes. However, networks trained on non-transparent orthographies are more likely to restore corrupted phonological segments with legal, coarser linguistic units (e.g. onset, coda). Our study therefore provides an explicit description of how differences in orthographic transparency can lead to varying strains and symptoms of the ‘literacy virus’.

Abstract

When processing language, the cognitive system has access to information from a range of modalities (e.g. auditory, visual) to support language processing. Language mediated visual attention studies have shown sensitivity of the listener to phonological, visual, and semantic similarity when processing a word. In a computational model of language mediated visual attention, that models spoken word processing as the parallel integration of information from phonological, semantic and visual processing streams, we simulate such effects of competition within modalities. Our simulations raised untested predictions about stronger and earlier effects of visual and semantic similarity compared to phonological similarity around the rhyme of the word. Two visual world studies confirmed these predictions. The model and behavioral studies suggest that, during spoken word comprehension, multimodal information can be recruited rapidly to constrain lexical selection to the extent that phonological rhyme information may exert little influence on this process.

Abstract

Multimodal integration is a central characteristic of human cognition. However our understanding of the interaction between modalities and its influence on behaviour is still in its infancy. This paper examines the value of the Hub & Spoke framework (Plaut, 2002; Rogers et al., 2004; Dilkina et al., 2008; 2010) as a tool for exploring multimodal interaction in cognition. We present a Hub and Spoke model of language–vision information interaction and report the model’s ability to replicate a range of phonological, visual and semantic similarity word-level effects reported in the Visual World Paradigm (Cooper, 1974; Tanenhaus et al, 1995). The model provides an explicit connection between the percepts of language and the distribution of eye gaze and demonstrates the scope of the Hub-and-Spoke architectural framework by modelling new aspects of multimodal cognition.

Abstract

Learning to read and write requires an individual to connect additional orthographic representations to pre-existing mappings between phonological and semantic representations of words. Past empirical results suggest that the process of learning to read and write (at least in alphabetic languages) elicits changes in the language processing system, by either increasing the cognitive efficiency of mapping between representations associated with a word, or by changing the granularity of phonological processing of spoken language, or through a combination of both. Behavioural effects of literacy have typically been assessed in offline explicit tasks that have addressed only phonological processing. However, a recent eye tracking study compared high and low literate participants on effects of phonology and semantics in processing measured implicitly using eye movements. High literates’ eye movements were more affected by phonological overlap in online speech than low literates, with only subtle differences observed in semantics. We determined whether these effects were due to cognitive efficiency and/or granularity of speech processing in a multimodal model of speech processing – the amodal shared resource model (ASR, Smith, Monaghan, & Huettig, 2013). We found that cognitive efficiency in the model had only a marginal effect on semantic processing and did not affect performance for phonological processing, whereas fine-grained versus coarse-grained phonological representations in the model simulated the high/low literacy effects on phonological processing, suggesting that literacy has a focused effect in changing the grain-size of phonological mappings.

Abstract

WDR5 is a broadly studied, highly conserved key protein involved in a wide array of biological functions. Among these functions, WDR5 is a part of several protein complexes that affect gene regulation via post-translational modification of histones. We collected data from 11 unrelated individuals with six different rare de novo germline missense variants in WDR5; one identical variant was found in five individuals, and another variant in two individuals. All individuals had neurodevelopmental disorders including speech/language delays (N=11), intellectual disability (N=9), epilepsy (N=7) and autism spectrum disorder (N=4). Additional phenotypic features included abnormal growth parameters (N=7), heart anomalies (N=2) and hearing loss (N=2). Three-dimensional protein structures indicate that all the residues affected by these variants are located at the surface of one side of the WDR5 protein. It is predicted that five out of the six amino acid substitutions disrupt interactions of WDR5 with RbBP5 and/or KMT2A/C, as part of the COMPASS (complex proteins associated with Set1) family complexes. Our experimental approaches in Drosophila melanogaster and human cell lines show normal protein expression, localization and protein-protein interactions for all tested variants. These results, together with the clustering of variants in a specific region of WDR5 and the absence of truncating variants so far, suggest that dominant-negative or gain-of-function mechanisms might be at play. All in all, we define a neurodevelopmental disorder associated with missense variants in WDR5 and a broad range of features. This finding highlights the important role of genes encoding COMPASS family proteins in neurodevelopmental disorders.

Abstract

We investigated early electrophysiological responses to spoken English words embedded in neutral sentence frames, using a lexical decision paradigm. As words unfold in time, similar-sounding lexical items compete for recognition within 200 milliseconds after word onset. A small number of studies have previously investigated event-related potentials in this time window in English and French, with results differing in direction of effects as well as component scalp distribution. Investigations of spoken-word recognition in Swedish have reported an early left-frontally distributed event-related potential that increases in amplitude as a function of the probability of a successful lexical match as the word unfolds. Results from the present study indicate that the same process may occur in English: we propose that increased certainty of a ‘word’ response in a lexical decision task is reflected in the amplitude of an early left-anterior brain potential beginning around 150 milliseconds after word onset. This in turn is proposed to be connected to the probabilistically driven activation of possible upcoming word forms.

Abstract

Background: The hypothalamus-pituitary-thyroid axis coordinates brain development and postdevelopmental function. Thyroid hormone (TH) variations, even within the normal range, have been associated with the risk of developing common psychiatric disorders, although the underlying mechanisms remain poorly understood.

Methods: To get new insight into the potentially shared mechanisms underlying thyroid dysfunction and psychiatric disorders, we performed a comprehensive analysis of multiple phenotypic and genotypic databases. We investigated the relationship of thyroid disorders with depression, bipolar disorder (BIP), and anxiety disorders (ANXs) in 497,726 subjects from U.K. Biobank. We subsequently investigated genetic correlations between thyroid disorders, thyrotropin (TSH), and free thyroxine (fT4) levels, with the genome-wide factors that predispose to psychiatric disorders. Finally, the observed global genetic correlations were furthermore pinpointed to specific local genomic regions.

Results: Hypothyroidism was positively associated with an increased risk of major depressive disorder (MDD; OR = 1.31, p = 5.29 × 10−89), BIP (OR = 1.55, p = 0.0038), and ANX (OR = 1.16, p = 6.22 × 10−8). Hyperthyroidism was associated with MDD (OR = 1.11, p = 0.0034) and ANX (OR = 1.34, p = 5.99 × 10−⁶). Genetically, strong coheritability was observed between thyroid disease and both major depressive (rg = 0.17, p = 2.7 × 10−⁴) and ANXs (rg = 0.17, p = 6.7 × 10−⁶). This genetic correlation was particularly strong at the major histocompatibility complex locus on chromosome 6 (p < 10−⁵), but further analysis showed that other parts of the genome also contributed to this global effect. Importantly, neither TSH nor fT4 levels were genetically correlated with mood disorders.

Conclusions: Our findings highlight an underlying association between autoimmune hypothyroidism and mood disorders, which is not mediated through THs and in which autoimmunity plays a prominent role. While these findings could shed new light on the potential ineffectiveness of treating (minor) variations in thyroid function in psychiatric disorders, further research is needed to identify the exact underlying molecular mechanisms.

Abstract

TBR1 is a neuron-specific transcription factor involved in brain development and implicated in a neurodevelopmental disorder (NDD) combining features of autism spectrum disorder (ASD), intellectual disability (ID) and speech delay. TBR1 has been previously shown to interact with a small number of transcription factors and co-factors also involved in NDDs (including CASK, FOXP1/2/4 and BCL11A), suggesting that the wider TBR1 interactome may have a significant bearing on normal and abnormal brain development. Here we have identified approximately 250 putative TBR1-interaction partners by affinity purification coupled to mass spectrometry. As well as known TBR1-interactors such as CASK, the identified partners include transcription factors and chromatin modifiers, along with ASD- and ID-related proteins. Five interaction candidates were independently validated using bioluminescence resonance energy transfer assays. We went on to test the interaction of these candidates with TBR1 protein variants implicated in cases of NDD. The assays uncovered disturbed interactions for NDD-associated variants and identified two distinct protein-binding domains of TBR1 that have essential roles in protein–protein interaction.

Abstract

The auditory scene is a mental representation of individual sounds extracted from the summed sound waveform reaching the ears of the listeners. Musical contexts represent particularly complex cases of auditory scenes. In such a scenario, melody may be seen as the main object moving on a background represented by the accompaniment. Both melody and accompaniment vary in time according to harmonic rules, forming a typical texture with melody in the most prominent, salient voice. In the present sparse acquisition functional magnetic resonance imaging study, we investigated the interplay between melody and accompaniment in trained pianists, by observing the activation responses elicited by processing: (1) melody placed in the upper and lower texture voices, leading to, respectively, a higher and lower auditory salience; (2) harmonic violations occurring in either the melody, the accompaniment, or both. The results indicated that the neural activation elicited by the processing of polyphonic compositions in expert musicians depends upon the upper versus lower position of the melodic line in the texture, and showed an overall greater activation for the harmonic processing of melody over accompaniment. Both these two predominant effects were characterized by the involvement of the posterior cingulate cortex and precuneus, among other associative brain regions. We discuss the prominent role of the posterior medial cortex in the processing of melodic and harmonic information in the auditory stream, and propose to frame this processing in relation to the cognitive construction of complex multimodal sensory imagery scenes.

Abstract

E-Prime, the software suite by Psychology Software Tools, is used for designing, developing and running custom psychological experiments. Aimed at students and researchers alike, this book provides a much needed, down-to-earth introduction into a wide range of experiments that can be set up using E-Prime. Many tutorials are provided to teach the reader how to develop experiments typical for the broad fields of psychological and cognitive science. Apart from explaining the basic structure of E-Prime and describing how it fits into daily scientific practice, this book also offers an introduction into programming using E-Prime’s own E-Basic language. The authors guide the readers step-by-step through the software, from an elementary to an advanced level, enabling them to benefit from the enormous possibilities for experimental design offered by E-Prime.

Abstract

Statistical learning, the ability to extract regularities from input (e.g., in language), is likely supported by learners’ prior expectations about how component units co-occur. In this study, we investigated how adults’ prior experience with sublexical regularities in their native language influences performance on an empirical language learning task. Forty German-speaking adults completed a speech repetition task in which they repeated eight-syllable sequences from two experimental languages: one containing disyllabic words comprised of frequently occurring German syllable transitions (naturalistic words) and the other containing words made from unattested syllable transitions (non-naturalistic words). The participants demonstrated learning from both naturalistic and non-naturalistic stimuli. However, learning was superior for the naturalistic sequences, indicating that the participants had used their existing distributional knowledge of German to extract the naturalistic words faster and more accurately than the non-naturalistic words. This finding supports theories of statistical learning as a form of chunking, whereby frequently co-occurring units become entrenched in long-term memory.

Abstract

OBJECTIVE: Genome-wide association studies (GWAS) of BMI are mostly undertaken under the assumption that "kg/m(2) " is an index of weight fully adjusted for height, but in general this is not true. The aim here was to assess the contribution of common genetic variation to a adjusted version of that phenotype which appropriately accounts for covariation in height in children. METHODS: A GWAS of height-adjusted BMI (BMI[x] = weight/height(x) ), calculated to be uncorrelated with height, in 5809 participants (mean age 9.9 years) from the Avon Longitudinal Study of Parents and Children (ALSPAC) was performed. RESULTS: GWAS based on BMI[x] yielded marked differences in genomewide results profile. SNPs in ADCY3 (adenylate cyclase 3) were associated at genome-wide significance level (rs11676272 (0.28 kg/m(3.1) change per allele G (0.19, 0.38), P = 6 × 10(-9) ). In contrast, they showed marginal evidence of association with conventional BMI [rs11676272 (0.25 kg/m(2) (0.15, 0.35), P = 6 × 10(-7) )]. Results were replicated in an independent sample, the Generation R study. CONCLUSIONS: Analysis of BMI[x] showed differences to that of conventional BMI. The association signal at ADCY3 appeared to be driven by a missense variant and it was strongly correlated with expression of this gene. Our work highlights the importance of well understood phenotype use (and the danger of convention) in characterising genetic contributions to complex traits.

Abstract

This study focuses on embodied uses of recognitional
demonstratives. While multimodal conversation analytic
studies have shown how gesture and speech interact in the
elaboration of exophoric references, little attention has been
given to the multimodal configuration of other types of
referential actions. Based on a video-recorded corpus of
professional meetings held in French, this qualitative study
shows that a subtype of deictic references, namely recognitional
references, are frequently associated with iconic gestures, thus
challenging the traditional distinction between exophoric and
endophoric uses of deixis.

Abstract

While a training model of cognitive intervention targets the improvement of particular skills through instruction and practice, an engagement model is based on the idea that being embedded in an intellectually and socially complex environment can impact cognition, perhaps even broadly, without explicit instruction. We contrasted these 2 models of cognitive enrichment by randomly assigning healthy older adults to a home-based inductive reasoning training program, a team-based competitive program in creative problem solving, or a wait-list control. As predicted, those in the training condition showed selective improvement in inductive reasoning. Those in the engagement condition, on the other hand, showed selective improvement in divergent thinking, a key ability exercised in creative problem solving. On average, then, both groups appeared to show ability-specific effects. However, moderators of change differed somewhat for those in the engagement and training interventions. Generally, those who started either intervention with a more positive cognitive profile showed more cognitive growth, suggesting that cognitive resources enabled individuals to take advantage of environmental enrichment. Only in the engagement condition did initial levels of openness and social network size moderate intervention effects on cognition, suggesting that comfort with novelty and an ability to manage social resources may be additional factors contributing to the capacity to take advantage of the environmental complexity associated with engagement. Collectively, these findings suggest that training and engagement models may offer alternative routes to cognitive resilience in late life

Abstract

In everyday interactions with one another, speakers not only say things but also do things like offer, complain, reject, and compliment. Through observation, it is possible to see that much of the time people unproblematically understand what others are doing. Research on conversation has further documented how speakers’ word choice, prosody, grammar, and gesture all help others to recognize what actions they are performing. In this study, we rely on spontaneous naturally occurring conversational data where people have trouble making their actions understood to examine what leads to ambiguous actions, bringing together prior research and identifying recurrent types of ambiguity that hinge on different dimensions of social action. We then discuss the range of costs and benefits for social actors when actions are clear versus ambiguous. Finally, we offer a conceptual model of how, at a microlevel, action ascription is done. Actions in interaction are building blocks for social relations; at each turn, an action can strengthen or strain the bond between two individuals. Thus, a unified theory of action ascription at a microlevel is an essential component for broader theories of social action and of how social actions produce, maintain, and revise the social world.

Abstract

How can we understand each other during communicative interactions? An influential suggestion holds that communicators are primed by each other’s behaviors, with associative mechanisms automatically coordinating the production of communicative signals and the comprehension of their meanings. An alternative suggestion posits that mutual understanding requires shared conceptualizations of a signal’s use, i.e., “conceptual pacts” that are abstracted away from specific experiences. Both accounts predict coherent neural dynamics across communicators, aligned either to the occurrence of a signal or to the dynamics of conceptual pacts. Using coherence spectral-density analysis of cerebral activity simultaneously measured in pairs of communicators, this study shows that establishing mutual understanding of novel signals synchronizes cerebral dynamics across communicators’ right temporal lobes. This interpersonal cerebral coherence occurred only within pairs with a shared communicative history, and at temporal scales independent from signals’ occurrences. These findings favor the notion that meaning emerges from shared conceptualizations of a signal’s use.

Abstract

Despite the ambiguity inherent in human communication, people are remarkably efficient in establishing mutual understanding. Studying how people communicate in novel settings provides a window into the mechanisms supporting the human competence to rapidly generate and understand novel shared symbols, a fundamental property of human communication. Previous work indicates that the right posterior superior temporal sulcus (pSTS) is involved when people understand the intended meaning of novel communicative actions. Here, we set out to test whether normal functioning of this cerebral structure is required for understanding novel communicative actions using inhibitory low-frequency repetitive transcranial magnetic stimulation (rTMS). A factorial experimental design contrasted two tightly matched stimulation sites (right pSTS vs. left MT+, i.e. a contiguous homotopic task-relevant region) and tasks (a communicative task vs. a visual tracking task that used the same sequences of stimuli). Overall task performance was not affected by rTMS, whereas changes in task performance over time were disrupted according to TMS site and task combinations. Namely, rTMS over pSTS led to a diminished ability to improve action understanding on the basis of recent communicative history, while rTMS over MT+ perturbed improvement in visual tracking over trials. These findings qualify the contributions of the right pSTS to human communicative abilities, showing that this region might be necessary for incorporating previous knowledge, accumulated during interactions with a communicative partner, to constrain the inferential process that leads to action understanding.

Abstract

Developmental studies show that it takes longer for
children learning spoken languages to acquire viewpointdependent
spatial relations (e.g., left-right, front-behind),
compared to ones that are not viewpoint-dependent (e.g.,
in, on, under). The current study investigates how
children learn to express viewpoint-dependent relations
in a sign language where depicted spatial relations can be
communicated in an analogue manner in the space in
front of the body or by using body-anchored signs (e.g.,
tapping the right and left hand/arm to mean left and
right). Our results indicate that the visual-spatial
modality might have a facilitating effect on learning to
express these spatial relations (especially in encoding of
left-right) in a sign language (i.e., Turkish Sign
Language) compared to a spoken language (i.e.,
Turkish).

Abstract

We investigate how the lexical nature of weak definites influences the phenomenon of direct object scrambling in Dutch. Earlier experiments have indicated that weak definites are more resistant to scrambling than strong definites. We examine how the notion of weak definiteness used in this experimental work can be reduced to lexical connectedness. We explore four different ways of quantifying the relation between a direct object and the verb. Our results show that predictability of a verb given the object (verb cloze probability) provides the best fit to the weak/strong distinction used in the earlier experiments

Abstract

To investigate the neural underpinnings of word decoding, and how it changes as a function of repeated exposure, we trained Dutch participants repeatedly over the course of a month of training to articulate a set of novel disyllabic input strings written in Greek script to avoid the use of familiar orthographic representations. The syllables in the input were phonotactically legal combinations but non-existent in the Dutch language, allowing us to assess their role in novel word decoding. Not only trained disyllabic pseudowords were tested but also pseudowords with recombined patterns of syllables to uncover the emergence of syllabic representations. We showed that with extensive training, articulation became faster and more accurate for the trained pseudowords. On the neural level, the initial stage of decoding was reflected by increased activity in visual attention areas of occipito-temporal and occipito-parietal cortices, and in motor coordination areas of the precentral gyrus and the inferior frontal gyrus. After one month of training, memory representations for holistic information (whole word unit) were established in areas encompassing the angular gyrus, the precuneus and the middle temporal gyrus. Syllabic representations also emerged through repeated training of disyllabic pseudowords, such that reading recombined syllables of the trained pseudowords showed similar brain activation to trained pseudowords and were articulated faster than novel combinations of letter strings used in the trained pseudowords.

Abstract

The complementary learning systems account of declarative memory suggests two distinct memory networks, a fast-mapping, episodic system involving the hippocampus, and a slower semantic memory system distributed across the neocortex in which new information is gradually integrated with existing representations. In this study, we investigated the extent to which these two networks are involved in the integration of novel words into the lexicon after extensive learning, and how the involvement of these networks changes after 24 hours. In particular, we explored whether having richer information at encoding influences the lexicalization trajectory. We trained participants with two sets of novel words, one where exposure was only to the words’ phonological forms (the form-only condition), and one where pictures of unfamiliar objects were associated with the words’ phonological forms (the picture-associated condition). A behavioral measure of lexical competition (indexing lexicalization) indicated stronger competition effects for the form-only words. Imaging (fMRI) results revealed greater involvement of phonological lexical processing areas immediately after training in the form-only condition, suggesting tight connections were formed between novel words and existing lexical entries already at encoding. Retrieval of picture-associated novel words involved the episodic/hippocampal memory system more extensively. Although lexicalization was weaker in the picture-associated condition, overall memory strength was greater when tested after a 24 hours’ delay, probably due to the availability of both episodic and lexical memory networks to aid retrieval. It appears that, during lexicalization of a novel word, the relative involvement of different memory networks differs according to the richness of the information about that word available at encoding.

Abstract

Not unlike the tonal system in Chinese, Japanese habitually attaches pitch accents to the production of words. However, in contrast to Chinese, few homophonic word-pairs are really distinguished by pitch accents (Shibata & Shibata, 1990). This predicts that pitch accent plays a small role in lexical selection for Japanese language comprehension. The present study investigated whether native Japanese speakers necessarily use pitch accent in the processing of accent-contrasted homophonic pairs (e.g., ame [LH] for 'candy' and ame [HI] for 'rain') measuring electroencephalographic (EEG) potentials. Electrophysiological evidence (i.e., N400) was obtained when a word was semantically incorrect for a given context but not for incorrectly accented homophones. This suggests that pitch accent indeed plays a minor role when understanding Japanese. (C) 2013 Elsevier Ltd. All rights reserved.

Abstract

The current study explored the role of sentential inference in connecting lexical/grammatical knowledge and overall text comprehension in foreign language learning. Using structural equation modeling (SEM), causal relationships were examined between four latent variables: lexical knowledge, grammatical knowledge, sentential inference, and text comprehension. The study analyzed 281 Chinese university students learning Japanese as a second language and compared two causal models: (1) the partially-mediated model, which suggests that lexical knowledge, grammatical knowledge, and sentential inference concurrently influence text comprehension, and (2) the wholly-mediated model, which posits that both lexical and grammatical knowledge impact sentential inference, which then further affects text comprehension. The SEM comparison analysis supported the wholly-mediated model, showing sequential causal relationships from lexical knowledge to sentential inference and then to text comprehension, without significant contribution from grammatical knowledge. The results indicate that sentential inference serves as a crucial bridge between lexical knowledge and text comprehension.

Abstract

This study is the first to report chronometric evidence on Tongan language production. It has been speculated that the mora plays an important role during Tongan phonological encoding. A mora follows the (C)V form, so /a/ and /ka/ (but not /k/) denote a mora in Tongan. Using a picture-word naming paradigm, Tongan native speakers named pictures containing superimposed non-word distractors. This task has been used before in Japanese, Korean, and Vietnamese to investigate the initially selected unit during phonological encoding (IPU). Compared to control distractors, both onset and mora overlapping distractors resulted in faster naming latencies. Several alternative explanations for the pattern of results - proficiency in English, knowledge of Latin script, and downstream effects - are discussed. However, we conclude that Tongan phonological encoding likely natively uses the phoneme, and not the mora, as the IPU..

Abstract

Attraction interference in language comprehension and production may be as a result of common or different processes. In the present paper, we investigate attraction interference during language comprehension, focusing on the contexts in which interference arises and the time-course of these effects. Using evidence from event-related brain potentials (ERPs) and sentence judgment times, we show that agreement attraction in comprehension is best explained as morphosyntactic interference during memory retrieval. This stands in contrast to attraction as a message-level process involving the representation of the subject NP's number features, which is a strong contributor to attraction in production. We thus argue that the cognitive antecedents of agreement attraction in comprehension are non-identical with those of attraction in production, and moreover, that attraction in comprehension is primarily a consequence of similarity-based interference in cue-based memory retrieval processes. We suggest that mechanisms responsible for attraction during language comprehension are a subset of those involved in language production.

Abstract

This study investigates how Japanese-speaking children learn interactional dependencies in conversations that determine the use of un, a token typically used as a positive response for yes-no questions, backchannel, and acknowledgement. We hypothesise that children learn to produce un appropriately by recognising different types of cues occurring in the immediately preceding turns. We built a set of generalised linear models on the longitudinal conversation data from seven children aged 1 to 5 years and their caregivers. Our models revealed that children not only increased their un production, but also learned to attend relevant cues in the preceding turns to understand when to respond by producing un. Children increasingly produced un when their interlocutors asked a yes-no question or signalled the continuation of their own speech. These results illustrate how children learn the probabilistic dependency between adjacent turns, and become able to participate in conversational interactions.

Abstract

This paper addresses the question how to compare reaction times computed by a computational model of speech comprehension with observed reaction times by participants. The question is based on the observation that reaction time sequences substantially differ per participant, which raises the issue of how exactly the model is to be assessed. Part of the variation in reaction time sequences is caused by the so-called local speed: the current reaction time correlates to some extent with a number of previous reaction times, due to slowly varying variations in attention, fatigue etc. This paper proposes a method, based on time series analysis, to filter the observed reaction times in order to separate the local speed effects. Results show that after such filtering the between-participant correlations increase as well as the average correlation between participant and model increases. The presented technique provides insights into relevant aspects that are to be taken into account when comparing reaction time sequences

Abstract

Temporal structure in the environment often has predictive value for anticipating the occurrence of forthcoming events. In this study we investigated the influence of two types of predictive temporal information on the perception of near-threshold auditory stimuli: 1) intrinsic temporal rhythmicity within an auditory stimulus stream and 2) temporally-predictive visual cues. We hypothesized that combining predictive temporal information within- and across-modality should decrease the threshold at which sounds are detected, beyond the advantage provided by each information source alone. Two experiments were conducted in which participants had to detect tones in noise. Tones were presented in either rhythmic or random sequences and were preceded by a temporally predictive visual signal in half of the trials. We show that detection intensities are lower for rhythmic (vs. random) and audiovisual (vs. auditory-only) presentation, independent from response bias, and that this effect is even greater for rhythmic audiovisual presentation. These results suggest that both types of temporal information are used to optimally process sounds that occur at expected points in time (resulting in enhanced detection), and that multiple temporal cues are combined to improve temporal estimates. Our findings underscore the flexibility and proactivity of the perceptual system which uses within- and across-modality temporal cues to anticipate upcoming events and process them optimally. (C) 2014 Elsevier Ltd. All rights reserved.

Abstract

When we comprehend language from speech, the phase of the neural response aligns with particular features of the speech input, resulting in a phenomenon referred to as neural tracking. In recent years, a large body of work has demonstrated the tracking of the acoustic envelope and abstract linguistic units at the phoneme and word levels, and beyond. However, the degree to which speech tracking is driven by acoustic edges of the signal, or by internally-generated linguistic units, or by the interplay of both, remains contentious. In this study, we used naturalistic story-listening to investigate (1) whether phoneme-level features are tracked over and above acoustic edges, (2) whether word entropy, which can reflect sentence- and discourse-level constraints, impacted the encoding of acoustic and phoneme-level features, and (3) whether the tracking of acoustic edges was enhanced or suppressed during comprehension of a first language (Dutch) compared to a statistically familiar but uncomprehended language (French). We first show that encoding models with phoneme-level linguistic features, in addition to acoustic features, uncovered an increased neural tracking response; this signal was further amplified in a comprehended language, putatively reflecting the transformation of acoustic features into internally generated phoneme-level representations. Phonemes were tracked more strongly in a comprehended language, suggesting that language comprehension functions as a neural filter over acoustic edges of the speech signal as it transforms sensory signals into abstract linguistic units. We then show that word entropy enhances neural tracking of both acoustic and phonemic features when sentence- and discourse-context are less constraining. When language was not comprehended, acoustic features, but not phonemic ones, were more strongly modulated, but in contrast, when a native language is comprehended, phoneme features are more strongly modulated. Taken together, our findings highlight the flexible modulation of acoustic, and phonemic features by sentence and discourse-level constraint in language comprehension, and document the neural transformation from speech perception to language comprehension, consistent with an account of language processing as a neural filter from sensory to abstract representations.

Abstract

Gesture is an important precursor of children’s early language development, for example, in the transition to multiword speech and as a predictor of later language abilities. However, it is unclear whether gestural input can influence children’s comprehension of complex grammatical constructions. In Study 1, 3- (M = 3 years 5 months) and 4-year-old (M = 4 years 6 months) children witnessed 2-participant actions described using the infrequent object-cleft-construction (OCC; It was the dog that the cat chased). Half saw an experimenter accompanying her descriptions with gestures representing the 2 participants and indicating the direction of action; the remaining children did not witness gesture. Children who witnessed gestures showed better comprehension of the OCC than those who did not witness gestures, both in and beyond the immediate physical context, but this benefit was restricted to the oldest 4-year-olds. In Study 2, a further group of older 4-year-old children (M = 4 years 7 months) witnessed the same 2-participant actions described by an experimenter and accompanied by gestures, but the gesture represented only the 2 participants and not the direction of the action. Again, a benefit of gesture was observed on subsequent comprehension of the OCC. We interpret these findings as demonstrating that representational cospeech gestures can help children comprehend complex linguistic structures by highlighting the roles played by the participants in the event.

Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA’s first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way

Abstract

We investigated 14-month-old infants’ expectations toward a third party addressee of communicative gestures and an instrumental action. Infants’ eye movements were tracked as they observed a person (the Gesturer) point, direct a palm-up request gesture, or reach toward an object, and another person (the Addressee) respond by grasping it. Infants’ looking patterns indicate that when the Gesturer pointed or used the palm-up request, infants anticipated that the Addressee would give the object to the Gesturer, suggesting that they ascribed a motive of request to the gestures. In contrast, when the Gesturer reached for the object, and in a control condition where no action took place, the infants did not anticipate the Addressee’s response. The results demonstrate that infants’ recognition of communicative gestures extends to others’ interactions, and that infants can anticipate how third-party addressees will respond to others’ gestures.

Abstract

PTEN Hamartoma Tumor Syndrome (PHTS) is an autosomal-dominant genetic condition underlying a subset of autism spectrum disorder (ASD) with macrocephaly. Caused by germline mutations in PTEN, PHTS also causes increased risks of multiple cancers via dysregulation of the PI3K and MAPK signaling pathways. Conditional knockout models have shown that neural Pten regulates social behavior, proliferation and cell size. Although much is known about how the intracellular localization of PTEN regulates signaling in cancer cell lines, we know little of how PTEN localization influences normal brain physiology and behavior. To address this, we generated a germline knock-in mouse model of cytoplasm-predominant Pten and characterized its behavioral and cellular phenotypes. The homozygous Ptenm3m4 mice have decreased total Pten levels including a specific drop in nuclear Pten and exhibit region-specific increases in brain weight. The Ptenm3m4 model displays sex-specific increases in social motivation, poor balance and normal recognition memory—a profile reminiscent of some individuals with high functioning ASD. The cytoplasm-predominant protein caused cellular hypertrophy limited to the soma and led to increased NG2 cell proliferation and accumulation of glia. The animals also exhibit significant astrogliosis and microglial activation, indicating a neuroinflammatory phenotype. At the signaling level, Ptenm3m4 mice show brain region-specific differences in Akt activation. These results demonstrate that differing alterations to the same autism-linked gene can cause distinct behavioral profiles. The Ptenm3m4 model is the first murine model of inappropriately elevated social motivation in the context of normal cognition and may expand the range of autism-related behaviors replicated in animal models.

Abstract

Distinct empathy deficits are often described in patients with conduct disorder (CD) and autism spectrum disorder (ASD) yet their neural underpinnings and the influence of comorbid Callous-Unemotional (CU) traits are unclear. This study compares the cognitive (CE) and affective empathy (AE) abilities of youth with CD and ASD, their potential neuroanatomical correlates, and the influence of CU traits on empathy. Adolescents and parents/caregivers completed empathy questionnaires (N = 148 adolescents, mean age = 15.16 years) and T1 weighted images were obtained from a subsample (N = 130). Group differences in empathy and the influence of CU traits were investigated using Bayesian analyses and Voxel-Based Morphometry with Threshold-Free Cluster Enhancement focusing on regions involved in AE (insula, amygdala, inferior frontal gyrus and cingulate cortex) and CE processes (ventromedial prefrontal cortex, temporoparietal junction, superior temporal gyrus, and precuneus). The ASD group showed lower parent-reported AE and CE scores and lower self-reported CE scores while the CD group showed lower parent-reported CE scores than controls. When accounting for the influence of CU traits no AE deficits in ASD and CE deficits in CD were found, but CE deficits in ASD remained. Across all participants, CU traits were negatively associated with gray matter volumes in anterior cingulate which extends into the mid cingulate, ventromedial prefrontal cortex, and precuneus. Thus, although co-occurring CU traits have been linked to global empathy deficits in reports and underlying brain structures, its influence on empathy aspects might be disorder-specific. Investigating the subdimensions of empathy may therefore help to identify disorder-specific empathy deficits.

Abstract

The ability to control one's vocal production is a major advantage in acoustic communication. Yet, not all species have the same level of control over their vocal output. Several bird species can interrupt their song upon hearing an external stimulus, but there is no evidence how flexible this behavior is. Most research on corvids focuses on their cognitive abilities, but few studies explore their vocal aptitudes. Recent research shows that crows can be experimentally trained to vocalize in response to a brief visual stimulus. Our study investigated vocal control abilities with a more ecologically embedded approach in rooks. We show that two rooks could spontaneously coordinate their vocalizations to a long-lasting stimulus (the sound of their small bathing pool being filled with a water hose), one of them adjusting roughly (in the second range) its vocalizations as the stimuli began and stopped. This exploratory study adds to the literature showing that corvids, a group of species capable of cognitive prowess, are indeed able to display good vocal control abilities.

Abstract

In 3 experiments, we investigated whether intonational phrase structure can be primed. In all experiments, participants listened to sentences in which the presence and location of intonational phrase boundaries were manipulated such that the recording included either no intonational phrase boundaries, a boundary in a structurally dispreferred location, a boundary in a preferred location, or boundaries in both locations. In Experiment 1, participants repeated the sentences to test whether they would reproduce the prosodic structure they had just heard. Experiments 2 and 3 used a prime–target paradigm to evaluate whether the intonational phrase structure heard in the prime sentence might influence that of a novel target sentence. Experiment 1 showed that participants did repeat back sentences that they had just heard with the original intonational phrase structure, yet Experiments 2 and 3 found that exposure to intonational phrase boundaries on prime trials did not influence how a novel target sentence was prosodically phrased. These results suggest that speakers may retain the intonational phrasing of a sentence, but this effect is not long-lived and does not generalize across unrelated sentences. Furthermore, these findings provide no evidence that intonational phrase structure is formulated during a planning stage that is separate from other sources of linguistic information.

Abstract

Tone languages are often reported to make use of utterancelevel intonation as well as of lexical tone. We test the alternative hypotheses that a) the coexistence of lexical tone and utterance-level intonation in tone languages results in a diminished functional load for intonation, and b) that lexical tone and intonation can coexist in tone languages without undermining each other’s functional load in a substantial way. In order to do this, we collected data from two large typological databases, and performed mixed-effects and phylogenetic regression analyses controlling for genealogical and areal factors to estimate the probability of a language exhibiting grammatical devices for encoding polar questions given its status as a tonal or an intonation-only language. Our analyses indicate that, while both tone and intonational languages tend to develop grammatical devices for marking polar questions above chance level, tone languages do this at a significantly higher frequency, with estimated probabilities ranging between 0.88 and .98. This statistical bias provides cross-linguistic empirical support to the view that the use of tonal features to mark lexical contrasts leads to a diminished functional load for utterance-level intonation.

Abstract

We investigate the realization and discrimination of lexical stress contrasts in pitch-unaccented words in phrase-medial position in Spanish, a context in which intonational pitch accents are frequently absent. Results from production and perception experiments show that in this context durational and intensity cues to stress are produced by speakers and used by listeners above chance level. However, due to substantial amounts of phonetic overlap between stress categories in production, and of numerous errors in the identification of stress categories in perception, we suggest that, in the absence of intonational cues, Spanish speakers engaged in online language use must rely on contextual information in order to distinguish stress contrasts.

Abstract

Neuregulin 1 (NRG1) and v-erb-a erythroblastic leukemia viral oncogene homolog 4 (ErbB4) have been extensively studied in schizophrenia susceptibility because of their pivotal role in key neurodevelopmental processes. One of the reasons for the inconsistencies in results could be the fact that the phenotype investigated has mostly the diagnosis of schizophrenia per se, which is widely heterogeneous, both clinically and biologically. In the present study we tested, in a large cohort of 461 schizophrenia patients recruited in Scotland, whether several SNPs in NRG1 and/or ErbB4 are associated with schizophrenia symptom dimensions as evaluated by the Positive and Negative Syndrome Scale (PANSS). We then followed up nominally significant results in a second cohort of 439 schizophrenia subjects recruited in Germany. Using linear regression, we observed two different groups of polymorphisms in NRG1 gene: one showing a nominal association with higher scores of the PANSS positive dimension and the other one with higher scores of the PANSS negative dimension. Regarding ErbB4, a small cluster located in the 5' end of the gene was detected, showing nominal association mainly with negative, general and total dimensions of the PANSS. These findings suggest that some regions of NRG1 and ErbB4 are functionally involved in biological processes that underlie some of the phenotypic manifestations of schizophrenia. Because of the lack of significant association after correction for multiple testing, our analyses should be considered as exploratory and hypothesis generating for future studies.

Abstract

Measuring the quality of metadata is only possible by assessing the quality of the underlying schema and the metadata instance. We propose some factors that are measurable automatically for metadata according to the CMD framework, taking into account the variability of schemas that can be defined in this framework. The factors include among others the number of elements, the (re-)use of reusable components, the number of filled in elements. The resulting score can serve as an indicator of the overall quality of the CMD instance, used for feedback to metadata providers or to provide an overview of the overall quality of metadata within a reposi-tory. The score is independent of specific schemas and generalizable. An overall assessment of harvested metadata is provided in form of statistical summaries and the distribution, based on a corpus of harvested metadata. The score is implemented in XQuery and can be used in tools, editors and repositories

Abstract

Natural human interaction requires us to produce and process many different signals, including speech, hand and head gestures, and facial expressions. These communicative signals, which occur in a variety of temporal relations with each other (e.g., parallel or temporally misaligned), must be rapidly processed as a coherent message by the receiver. In this contribution, we introduce the notion of interactionally embedded, affordance-driven gestalt perception as a framework that can explain how this rapid processing of multimodal signals is achieved as efficiently as it is. We discuss empirical evidence showing how basic principles of gestalt perception can explain some aspects of unimodal phenomena such as verbal language processing and visual scene perception but require additional features to explain multimodal human communication. We propose a framework in which high-level gestalt predictions are continuously updated by incoming sensory input, such as unfolding speech and visual signals. We outline the constituent processes that shape high-level gestalt perception and their role in perceiving relevance and prägnanz. Finally, we provide testable predictions that arise from this multimodal interactionally embedded gestalt-perception framework. This review and framework therefore provide a theoretically motivated account of how we may understand the highly complex, multimodal behaviors inherent in natural social interaction.

Abstract

In conversation, individuals work together to achieve communicative goals, complementing and aligning language and body with each other. An important emerging question is whether interlocutors entrain with one another equally across linguistic levels (e.g., lexical, syntactic, and semantic) and modalities (i.e., speech and gesture), or whether there are complementary patterns of behaviors, with some levels or modalities diverging and others converging in coordinated fashions. This study assesses how kinematic and linguistic entrainment interact with one another across levels of measurement, and according to communicative context. We analyzed data from two matched corpora of dyadic interaction between—respectively—Danish and Norwegian native speakers engaged in affiliative conversations and task-oriented conversations. We assessed linguistic entrainment at the lexical, syntactic, and semantic level, and kinetic alignment of the head and hands using video-based motion tracking and dynamic time warping. We tested whether—across the two languages—linguistic alignment correlates with kinetic alignment, and whether these kinetic-linguistic associations are modulated either by the type of conversation or by the language spoken. We found that kinetic entrainment was positively associated with low-level linguistic (i.e., lexical) entrainment, while negatively associated with high-level linguistic (i.e., semantic) entrainment, in a cross-linguistically robust way. Our findings suggest that conversation makes use of a dynamic coordination of similarity and complementarity both between individuals as well as between different communicative modalities, and provides evidence for a multimodal, interpersonal synergy account of interaction.

Abstract

When experienced in-person, engagement with art has been associated with positive outcomes in well-being and mental health. However, especially in the last decade, art viewing, cultural engagement, and even ‘trips’ to museums have begun to take place online, via computers, smartphones, tablets, or in virtual reality. Similarly, to what has been reported for in-person visits, online art engagements—easily accessible from personal devices—have also been associated to well-being impacts. However, a broader understanding of for whom and how online-delivered art might have well-being impacts is still lacking. In the present study, we used a Monet interactive art exhibition from Google Arts and Culture to deepen our understanding of the role of pleasure, meaning, and individual differences in the responsiveness to art. Beyond replicating the previous group-level effects, we confirmed our pre-registered hypothesis that trait-level inter-individual differences in aesthetic responsiveness predict some of the benefits that online art viewing has on well-being and further that such inter-individual differences at the trait level were mediated by subjective experiences of pleasure and especially meaningfulness felt during the online-art intervention. The role that participants' experiences play as a possible mechanism during art interventions is discussed in light of recent theoretical models.