This article, part of a 10 language comparative project on question–response sequences, discusses these sequences in American English conversation. The data are video-taped spontaneous naturally occurring conversations involving two to five adults. Relying on these data I document the basic distributional patterns of types of questions asked (polar, Q-word or alternative as well as sub-types), types of social actions implemented by these questions (e.g., repair initiations, requests for confirmation, offers or requests for information), and types of responses (e.g., repetitional answers or yes/no tokens). I show that declarative questions are used more commonly in conversation than would be suspected by traditional grammars of English and questions are used for a wider range of functions than grammars would suggest. Finally, this article offers distributional support for the idea that responses that are better “fitted” with the question are preferred.